node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SDE15054.1 | SDE90515.1 | SAMN05421636_103416 | SAMN05421636_108249 | Quinol:cytochrome c oxidoreductase iron-sulfur protein precursor. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.600 |
SDE15054.1 | SDE90550.1 | SAMN05421636_103416 | SAMN05421636_108250 | Quinol:cytochrome c oxidoreductase iron-sulfur protein precursor. | 5-methyltetrahydrofolate--homocysteine methyltransferase. | 0.483 |
SDE15054.1 | fumC | SAMN05421636_103416 | SAMN05421636_107220 | Quinol:cytochrome c oxidoreductase iron-sulfur protein precursor. | Fumarase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. | 0.837 |
SDE15054.1 | purN | SAMN05421636_103416 | SAMN05421636_10999 | Quinol:cytochrome c oxidoreductase iron-sulfur protein precursor. | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.820 |
SDE15054.1 | purU | SAMN05421636_103416 | SAMN05421636_10353 | Quinol:cytochrome c oxidoreductase iron-sulfur protein precursor. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.825 |
SDE90515.1 | SDE15054.1 | SAMN05421636_108249 | SAMN05421636_103416 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Quinol:cytochrome c oxidoreductase iron-sulfur protein precursor. | 0.600 |
SDE90515.1 | SDE90550.1 | SAMN05421636_108249 | SAMN05421636_108250 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 5-methyltetrahydrofolate--homocysteine methyltransferase. | 0.999 |
SDE90515.1 | gcvT | SAMN05421636_108249 | SAMN05421636_107297 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.906 |
SDE90515.1 | glyA | SAMN05421636_108249 | SAMN05421636_104120 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.901 |
SDE90515.1 | purU | SAMN05421636_108249 | SAMN05421636_10353 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.885 |
SDE90550.1 | SDE15054.1 | SAMN05421636_108250 | SAMN05421636_103416 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Quinol:cytochrome c oxidoreductase iron-sulfur protein precursor. | 0.483 |
SDE90550.1 | SDE90515.1 | SAMN05421636_108250 | SAMN05421636_108249 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.999 |
SDE90550.1 | SDE91579.1 | SAMN05421636_108250 | SAMN05421636_108287 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | 2TM domain-containing protein. | 0.771 |
SDE90550.1 | folD | SAMN05421636_108250 | SAMN05421636_103194 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.567 |
SDE90550.1 | gcvT | SAMN05421636_108250 | SAMN05421636_107297 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.915 |
SDE90550.1 | glyA | SAMN05421636_108250 | SAMN05421636_104120 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.901 |
SDE90550.1 | purN | SAMN05421636_108250 | SAMN05421636_10999 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.899 |
SDE90550.1 | purU | SAMN05421636_108250 | SAMN05421636_10353 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.891 |
SDE91579.1 | SDE90550.1 | SAMN05421636_108287 | SAMN05421636_108250 | 2TM domain-containing protein. | 5-methyltetrahydrofolate--homocysteine methyltransferase. | 0.771 |
SDE91579.1 | folD | SAMN05421636_108287 | SAMN05421636_103194 | 2TM domain-containing protein. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.421 |