STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PSEN1Presenilin 1. (470 aa)    
Predicted Functional Partners:
NCSTN
Nicastrin.
   
 0.970
PSENEN
Gamma-secretase subunit PEN-2.
    
 0.965
ENSPMRP00000020473
Gamma-secretase subunit Aph-1b-like.
   
 0.906
APH1A
Gamma-secretase subunit APH-1A.
   
 0.906
APP
Amyloid-beta precursor protein isoform X1.
    
 
 0.840
NOTCH1
Neurogenic locus notch homolog protein 1 isoform X1.
    
 0.798
CTNNB1
Catenin beta 1.
    
 
 0.660
TMBIM6
Bax inhibitor 1.
    
 
 0.656
APLP2
Amyloid-like protein 2 isoform X1.
    
 
 0.643
NBR1
Next to BRCA1 gene 1 protein isoform X1.
   
 
 0.606
Your Current Organism:
Podarcis muralis
NCBI taxonomy Id: 64176
Other names: Common wall lizard, Lacerrta muralis, Mauereidechse, P. muralis
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.