node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADZ83267.1 | hisG | Clole_1541 | Clole_2490 | KEGG: ccb:Clocel_3484 phosphoribosyltransferase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.844 |
ADZ83267.1 | hisI | Clole_1541 | Clole_2481 | KEGG: ccb:Clocel_3484 phosphoribosyltransferase. | TIGRFAM: Phosphoribosyl-ATP pyrophosphohydrolase; KEGG: cth:Cthe_2889 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; PFAM: Phosphoribosyl-AMP cyclohydrolase; Phosphoribosyl-ATP pyrophosphohydrolase-like; In the N-terminal section; belongs to the PRA-CH family. | 0.524 |
ADZ83267.1 | hisZ | Clole_1541 | Clole_2491 | KEGG: ccb:Clocel_3484 phosphoribosyltransferase. | histidyl-tRNA synthetase 2; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.819 |
ADZ83267.1 | prs | Clole_1541 | Clole_1101 | KEGG: ccb:Clocel_3484 phosphoribosyltransferase. | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. | 0.920 |
hisA | hisB | Clole_2483 | Clole_2485 | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; PFAM: Histidine biosynthesis; TIGRFAM: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HisA; HAMAP: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; KEGG: cpy:Cphy_2783 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | KEGG: cac:CA_C0938 imidazoleglycerol-phosphate dehydratase; PFAM: Imidazoleglycerol-phosphate dehydratase. | 0.997 |
hisA | hisC | Clole_2483 | Clole_2488 | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; PFAM: Histidine biosynthesis; TIGRFAM: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HisA; HAMAP: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; KEGG: cpy:Cphy_2783 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | TIGRFAM: Histidinol-phosphate aminotransferase; KEGG: cce:Ccel_0383 histidinol-phosphate aminotransferase; PFAM: Aminotransferase, class I/classII; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.947 |
hisA | hisD | Clole_2483 | Clole_2489 | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; PFAM: Histidine biosynthesis; TIGRFAM: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HisA; HAMAP: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; KEGG: cpy:Cphy_2783 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.992 |
hisA | hisF | Clole_2483 | Clole_2482 | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; PFAM: Histidine biosynthesis; TIGRFAM: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HisA; HAMAP: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; KEGG: cpy:Cphy_2783 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.996 |
hisA | hisG | Clole_2483 | Clole_2490 | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; PFAM: Histidine biosynthesis; TIGRFAM: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HisA; HAMAP: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; KEGG: cpy:Cphy_2783 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.990 |
hisA | hisH | Clole_2483 | Clole_2484 | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; PFAM: Histidine biosynthesis; TIGRFAM: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HisA; HAMAP: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; KEGG: cpy:Cphy_2783 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisA | hisI | Clole_2483 | Clole_2481 | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; PFAM: Histidine biosynthesis; TIGRFAM: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HisA; HAMAP: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; KEGG: cpy:Cphy_2783 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | TIGRFAM: Phosphoribosyl-ATP pyrophosphohydrolase; KEGG: cth:Cthe_2889 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; PFAM: Phosphoribosyl-AMP cyclohydrolase; Phosphoribosyl-ATP pyrophosphohydrolase-like; In the N-terminal section; belongs to the PRA-CH family. | 0.999 |
hisA | hisZ | Clole_2483 | Clole_2491 | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; PFAM: Histidine biosynthesis; TIGRFAM: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HisA; HAMAP: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; KEGG: cpy:Cphy_2783 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | histidyl-tRNA synthetase 2; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.932 |
hisB | hisA | Clole_2485 | Clole_2483 | KEGG: cac:CA_C0938 imidazoleglycerol-phosphate dehydratase; PFAM: Imidazoleglycerol-phosphate dehydratase. | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; PFAM: Histidine biosynthesis; TIGRFAM: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HisA; HAMAP: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; KEGG: cpy:Cphy_2783 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.997 |
hisB | hisC | Clole_2485 | Clole_2488 | KEGG: cac:CA_C0938 imidazoleglycerol-phosphate dehydratase; PFAM: Imidazoleglycerol-phosphate dehydratase. | TIGRFAM: Histidinol-phosphate aminotransferase; KEGG: cce:Ccel_0383 histidinol-phosphate aminotransferase; PFAM: Aminotransferase, class I/classII; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.999 |
hisB | hisD | Clole_2485 | Clole_2489 | KEGG: cac:CA_C0938 imidazoleglycerol-phosphate dehydratase; PFAM: Imidazoleglycerol-phosphate dehydratase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.998 |
hisB | hisF | Clole_2485 | Clole_2482 | KEGG: cac:CA_C0938 imidazoleglycerol-phosphate dehydratase; PFAM: Imidazoleglycerol-phosphate dehydratase. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.998 |
hisB | hisG | Clole_2485 | Clole_2490 | KEGG: cac:CA_C0938 imidazoleglycerol-phosphate dehydratase; PFAM: Imidazoleglycerol-phosphate dehydratase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.991 |
hisB | hisH | Clole_2485 | Clole_2484 | KEGG: cac:CA_C0938 imidazoleglycerol-phosphate dehydratase; PFAM: Imidazoleglycerol-phosphate dehydratase. | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisB | hisI | Clole_2485 | Clole_2481 | KEGG: cac:CA_C0938 imidazoleglycerol-phosphate dehydratase; PFAM: Imidazoleglycerol-phosphate dehydratase. | TIGRFAM: Phosphoribosyl-ATP pyrophosphohydrolase; KEGG: cth:Cthe_2889 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; PFAM: Phosphoribosyl-AMP cyclohydrolase; Phosphoribosyl-ATP pyrophosphohydrolase-like; In the N-terminal section; belongs to the PRA-CH family. | 0.999 |
hisB | hisZ | Clole_2485 | Clole_2491 | KEGG: cac:CA_C0938 imidazoleglycerol-phosphate dehydratase; PFAM: Imidazoleglycerol-phosphate dehydratase. | histidyl-tRNA synthetase 2; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.961 |