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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADZ84901.1Phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: AICARFT/IMPCHase bienzyme, transformylase domain; KEGG: ere:EUBREC_1567 5-aminoimidazole-4-carboxamide ribonucleotide transformylase; SMART: AICARFT/IMPCHase bienzyme, transformylase domain. (391 aa)    
Predicted Functional Partners:
ADZ83191.1
TIGRFAM: Phosphoribosylformylglycinamidine synthase, FGAM; KEGG: cac:CA_C1655 bifunctional phosphoribosylformylglycinamidine synthase; PFAM: AIR synthase-related protein, C-terminal; AIR synthase-related protein.
 
  
 0.999
purN
Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
 0.998
ADZ84171.1
TIGRFAM: Adenylosuccinate lyase; KEGG: cth:Cthe_0741 adenylosuccinate lyase; PFAM: Lyase 1, N-terminal; Adenylosuccinate lyase C-terminal metazoa/fungi.
  
 0.993
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 0.992
ADZ84902.1
PFAM: Inosine monophosphate cyclohydrolase-like; KEGG: ere:EUBREC_1566 hypothetical protein.
 
  
 0.990
fhs
KEGG: eel:EUBELI_01474 formate--tetrahydrofolate ligase; PFAM: Formate-tetrahydrofolate ligase, FTHFS; Belongs to the formate--tetrahydrofolate ligase family.
  
 0.983
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
  
 0.982
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
 
 0.980
purD
Phosphoribosylamine/glycine ligase; TIGRFAM: Phosphoribosylglycinamide synthetase; KEGG: elm:ELI_1205 hypothetical protein; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; Belongs to the GARS family.
 
 
 0.969
ADZ85908.1
PFAM: IMP dehydrogenase/GMP reductase; Cystathionine beta-synthase, core; KEGG: elm:ELI_1158 IMP dehydrogenase; SMART: Cystathionine beta-synthase, core.
 
 
 0.969
Your Current Organism:
Cellulosilyticum lentocellum
NCBI taxonomy Id: 642492
Other names: C. lentocellum DSM 5427, Cellulosilyticum lentocellum DSM 5427, Clostridium lentocellum ATCC 49066, Clostridium lentocellum DSM 5427, Clostridium lentocellum str. DSM 5427, Clostridium lentocellum strain DSM 5427
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