| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADZ82370.1 | ADZ82845.1 | Clole_0636 | Clole_1115 | KEGG: sad:SAAV_0686 hypothetical protein. | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.902 |
| ADZ82370.1 | ADZ83625.1 | Clole_0636 | Clole_1905 | KEGG: sad:SAAV_0686 hypothetical protein. | TIGRFAM: Hypoxanthine phosphoribosyl transferase; KEGG: tte:TTE2394 hypoxanthine-guanine phosphoribosyltransferase; PFAM: Phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.900 |
| ADZ82370.1 | ADZ84901.1 | Clole_0636 | Clole_3207 | KEGG: sad:SAAV_0686 hypothetical protein. | Phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: AICARFT/IMPCHase bienzyme, transformylase domain; KEGG: ere:EUBREC_1567 5-aminoimidazole-4-carboxamide ribonucleotide transformylase; SMART: AICARFT/IMPCHase bienzyme, transformylase domain. | 0.900 |
| ADZ82370.1 | ADZ84902.1 | Clole_0636 | Clole_3208 | KEGG: sad:SAAV_0686 hypothetical protein. | PFAM: Inosine monophosphate cyclohydrolase-like; KEGG: ere:EUBREC_1566 hypothetical protein. | 0.900 |
| ADZ82370.1 | ADZ85073.1 | Clole_0636 | Clole_3383 | KEGG: sad:SAAV_0686 hypothetical protein. | TIGRFAM: Hypoxanthine phosphoribosyl transferase; KEGG: bpb:bpr_I2906 hypoxanthine phosphoribosyltransferase Hpt; PFAM: Phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.900 |
| ADZ82370.1 | ADZ85908.1 | Clole_0636 | Clole_4236 | KEGG: sad:SAAV_0686 hypothetical protein. | PFAM: IMP dehydrogenase/GMP reductase; Cystathionine beta-synthase, core; KEGG: elm:ELI_1158 IMP dehydrogenase; SMART: Cystathionine beta-synthase, core. | 0.900 |
| ADZ82370.1 | guaB | Clole_0636 | Clole_3329 | KEGG: sad:SAAV_0686 hypothetical protein. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.900 |
| ADZ82370.1 | purA | Clole_0636 | Clole_1086 | KEGG: sad:SAAV_0686 hypothetical protein. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.902 |
| ADZ82845.1 | ADZ82370.1 | Clole_1115 | Clole_0636 | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | KEGG: sad:SAAV_0686 hypothetical protein. | 0.902 |
| ADZ82845.1 | ADZ83625.1 | Clole_1115 | Clole_1905 | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | TIGRFAM: Hypoxanthine phosphoribosyl transferase; KEGG: tte:TTE2394 hypoxanthine-guanine phosphoribosyltransferase; PFAM: Phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.905 |
| ADZ82845.1 | ADZ84901.1 | Clole_1115 | Clole_3207 | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: AICARFT/IMPCHase bienzyme, transformylase domain; KEGG: ere:EUBREC_1567 5-aminoimidazole-4-carboxamide ribonucleotide transformylase; SMART: AICARFT/IMPCHase bienzyme, transformylase domain. | 0.918 |
| ADZ82845.1 | ADZ84902.1 | Clole_1115 | Clole_3208 | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | PFAM: Inosine monophosphate cyclohydrolase-like; KEGG: ere:EUBREC_1566 hypothetical protein. | 0.900 |
| ADZ82845.1 | ADZ85073.1 | Clole_1115 | Clole_3383 | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | TIGRFAM: Hypoxanthine phosphoribosyl transferase; KEGG: bpb:bpr_I2906 hypoxanthine phosphoribosyltransferase Hpt; PFAM: Phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.905 |
| ADZ82845.1 | ADZ85908.1 | Clole_1115 | Clole_4236 | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | PFAM: IMP dehydrogenase/GMP reductase; Cystathionine beta-synthase, core; KEGG: elm:ELI_1158 IMP dehydrogenase; SMART: Cystathionine beta-synthase, core. | 0.945 |
| ADZ82845.1 | guaB | Clole_1115 | Clole_3329 | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.928 |
| ADZ82845.1 | purA | Clole_1115 | Clole_1086 | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.945 |
| ADZ83191.1 | ADZ84901.1 | Clole_1465 | Clole_3207 | TIGRFAM: Phosphoribosylformylglycinamidine synthase, FGAM; KEGG: cac:CA_C1655 bifunctional phosphoribosylformylglycinamidine synthase; PFAM: AIR synthase-related protein, C-terminal; AIR synthase-related protein. | Phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: AICARFT/IMPCHase bienzyme, transformylase domain; KEGG: ere:EUBREC_1567 5-aminoimidazole-4-carboxamide ribonucleotide transformylase; SMART: AICARFT/IMPCHase bienzyme, transformylase domain. | 0.996 |
| ADZ83191.1 | ADZ84902.1 | Clole_1465 | Clole_3208 | TIGRFAM: Phosphoribosylformylglycinamidine synthase, FGAM; KEGG: cac:CA_C1655 bifunctional phosphoribosylformylglycinamidine synthase; PFAM: AIR synthase-related protein, C-terminal; AIR synthase-related protein. | PFAM: Inosine monophosphate cyclohydrolase-like; KEGG: ere:EUBREC_1566 hypothetical protein. | 0.531 |
| ADZ83191.1 | ADZ85908.1 | Clole_1465 | Clole_4236 | TIGRFAM: Phosphoribosylformylglycinamidine synthase, FGAM; KEGG: cac:CA_C1655 bifunctional phosphoribosylformylglycinamidine synthase; PFAM: AIR synthase-related protein, C-terminal; AIR synthase-related protein. | PFAM: IMP dehydrogenase/GMP reductase; Cystathionine beta-synthase, core; KEGG: elm:ELI_1158 IMP dehydrogenase; SMART: Cystathionine beta-synthase, core. | 0.838 |
| ADZ83191.1 | guaB | Clole_1465 | Clole_3329 | TIGRFAM: Phosphoribosylformylglycinamidine synthase, FGAM; KEGG: cac:CA_C1655 bifunctional phosphoribosylformylglycinamidine synthase; PFAM: AIR synthase-related protein, C-terminal; AIR synthase-related protein. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.889 |
