STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SDS00602.1Homoserine O-acetyltransferase; Belongs to the AB hydrolase superfamily. MetX family. (360 aa)    
Predicted Functional Partners:
SDT19241.1
Cystathionine gamma-synthase.
 
  
 0.935
SDS51208.1
Cystathionine gamma-lyase.
 
  
 0.931
SDR98349.1
Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
  
 
 0.914
SDS51495.1
Cystathionine beta-synthase.
  
 
 0.911
SDT13922.1
Homoserine dehydrogenase.
  
 
 0.901
SDS70594.1
Methyltransferase domain-containing protein.
  
  
 0.873
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
     
 0.850
ilvA
L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
  
 
 0.846
SDR96606.1
Phosphoserine phosphatase.
   
 
  0.775
SDR73341.1
Cysteine synthase.
    
 0.768
Your Current Organism:
Marmoricola scoriae
NCBI taxonomy Id: 642780
Other names: DSM 22127, JCM 17444, KCTC 19597, M. scoriae, Marmoricola scoriae Lee and Lee 2010, Marmoricola sp. Sco-D01, strain Sco-D01
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