node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Daes_1020 | Daes_1744 | Daes_1020 | Daes_1744 | PFAM: pyruvate carboxyltransferase; KEGG: dsa:Desal_0448 pyruvate carboxyltransferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | KEGG: dsa:Desal_1998 putative alpha-isopropylmalate/homocitrate synthase family transferase; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain-containing protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.926 |
Daes_1020 | ilvC | Daes_1020 | Daes_1773 | PFAM: pyruvate carboxyltransferase; KEGG: dsa:Desal_0448 pyruvate carboxyltransferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.859 |
Daes_1020 | ilvD | Daes_1020 | Daes_0824 | PFAM: pyruvate carboxyltransferase; KEGG: dsa:Desal_0448 pyruvate carboxyltransferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | TIGRFAM: dihydroxy-acid dehydratase; KEGG: dsa:Desal_3776 dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.896 |
Daes_1020 | leuA | Daes_1020 | Daes_1912 | PFAM: pyruvate carboxyltransferase; KEGG: dsa:Desal_0448 pyruvate carboxyltransferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.925 |
Daes_1020 | leuB | Daes_1020 | Daes_1909 | PFAM: pyruvate carboxyltransferase; KEGG: dsa:Desal_0448 pyruvate carboxyltransferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.926 |
Daes_1020 | leuC | Daes_1020 | Daes_1911 | PFAM: pyruvate carboxyltransferase; KEGG: dsa:Desal_0448 pyruvate carboxyltransferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Homoaconitate hydratase family protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.877 |
Daes_1020 | leuD | Daes_1020 | Daes_1910 | PFAM: pyruvate carboxyltransferase; KEGG: dsa:Desal_0448 pyruvate carboxyltransferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 0.905 |
Daes_1223 | ilvC | Daes_1223 | Daes_1773 | KEGG: dsa:Desal_2029 threonine synthase; TIGRFAM: threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.770 |
Daes_1223 | ilvD | Daes_1223 | Daes_0824 | KEGG: dsa:Desal_2029 threonine synthase; TIGRFAM: threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit. | TIGRFAM: dihydroxy-acid dehydratase; KEGG: dsa:Desal_3776 dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.602 |
Daes_1223 | leuA | Daes_1223 | Daes_1912 | KEGG: dsa:Desal_2029 threonine synthase; TIGRFAM: threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.459 |
Daes_1223 | leuB | Daes_1223 | Daes_1909 | KEGG: dsa:Desal_2029 threonine synthase; TIGRFAM: threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.572 |
Daes_1223 | leuC | Daes_1223 | Daes_1911 | KEGG: dsa:Desal_2029 threonine synthase; TIGRFAM: threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit. | Homoaconitate hydratase family protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.532 |
Daes_1223 | leuD | Daes_1223 | Daes_1910 | KEGG: dsa:Desal_2029 threonine synthase; TIGRFAM: threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 0.858 |
Daes_1744 | Daes_1020 | Daes_1744 | Daes_1020 | KEGG: dsa:Desal_1998 putative alpha-isopropylmalate/homocitrate synthase family transferase; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain-containing protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. | PFAM: pyruvate carboxyltransferase; KEGG: dsa:Desal_0448 pyruvate carboxyltransferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.926 |
Daes_1744 | Daes_2552 | Daes_1744 | Daes_2552 | KEGG: dsa:Desal_1998 putative alpha-isopropylmalate/homocitrate synthase family transferase; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain-containing protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. | PFAM: Pyruvate kinase barrel; Pyruvate kinase alpha/beta; manually curated; KEGG: tgr:Tgr7_2890 pyruvate kinase; TIGRFAM: pyruvate kinase; Belongs to the pyruvate kinase family. | 0.820 |
Daes_1744 | Daes_2995 | Daes_1744 | Daes_2995 | KEGG: dsa:Desal_1998 putative alpha-isopropylmalate/homocitrate synthase family transferase; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain-containing protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. | PFAM: malic protein NAD-binding; malic protein domain protein; KEGG: dsa:Desal_0725 malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)). | 0.830 |
Daes_1744 | ilvC | Daes_1744 | Daes_1773 | KEGG: dsa:Desal_1998 putative alpha-isopropylmalate/homocitrate synthase family transferase; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain-containing protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.818 |
Daes_1744 | ilvD | Daes_1744 | Daes_0824 | KEGG: dsa:Desal_1998 putative alpha-isopropylmalate/homocitrate synthase family transferase; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain-containing protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. | TIGRFAM: dihydroxy-acid dehydratase; KEGG: dsa:Desal_3776 dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.980 |
Daes_1744 | leuA | Daes_1744 | Daes_1912 | KEGG: dsa:Desal_1998 putative alpha-isopropylmalate/homocitrate synthase family transferase; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain-containing protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.923 |
Daes_1744 | leuB | Daes_1744 | Daes_1909 | KEGG: dsa:Desal_1998 putative alpha-isopropylmalate/homocitrate synthase family transferase; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain-containing protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.862 |