STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Slip_0207KEGG: vcj:VCD_000591 hypothetical protein; SPTR: Q9KLL5 Putative uncharacterized protein. (725 aa)    
Predicted Functional Partners:
sbcD
Nuclease SbcCD, D subunit; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family.
  
 0.989
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
  
 0.951
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
 0.840
recA
recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 0.820
Slip_1509
COGs: COG1793 ATP-dependent DNA ligase; InterPro IPR016027:IPR012310:IPR016059; KEGG: swo:Swol_1123 DNA ligase, putative; PFAM: ATP dependent DNA ligase; SPTR: C0GF58 DNA polymerase LigD, ligase domain protein; PFAM: ATP dependent DNA ligase domain; ATP dependent DNA ligase C terminal region; TIGRFAM: DNA polymerase LigD, ligase domain.
   
 0.745
Slip_0591
Helicase c2; COGs: COG1199 Rad3-related DNA helicase; InterPro IPR014013:IPR014001:IPR006555; KEGG: gau:GAU_1256 putative ATP-dependent DNA helicase; SMART: helicase c2; DEAD-like helicase; SPTR: C1F796 Putative DnaQ family exonuclease/DinG family helicase; PFAM: DEAD/DEAH box helicase.
   
 0.673
Slip_1276
KEGG: tai:Taci_1497 hypothetical protein; SPTR: Q2N521 Virulence associated protein.
  
 0.665
Slip_1388
RNA-metabolising metallo-beta-lactamase; COGs: COG1236 exonuclease of the beta-lactamase fold involved in RNA processing; InterPro IPR011108; KEGG: swo:Swol_0305 RNA-metabolising metallo-beta-lactamase; PFAM: RNA-metabolising metallo-beta-lactamase; SPTR: Q0B056 RNA-metabolising metallo-beta-lactamase; PFAM: Metallo-beta-lactamase superfamily; RNA-metabolising metallo-beta-lactamase; Beta-Casp domain.
   
 0.640
Slip_2143
UMUC domain protein DNA-repair protein; COGs: COG0389 Nucleotidyltransferase/DNA polymerase involved in DNA repair; InterPro IPR017963:IPR001126; KEGG: tte:TTE0254 nucleotidyltransferase/DNA polymerase involved in DNA repair; PFAM: UMUC domain protein DNA-repair protein; SPTR: C1WS49 Nucleotidyltransferase/DNA polymerase involved in DNA repair; manually curated; PFAM: impB/mucB/samB family.
  
 0.605
Slip_1245
FHA domain containing protein; InterPro IPR008984:IPR000253; KEGG: ere:EUBREC_1112 hypothetical protein; PFAM: Forkhead-associated protein; SMART: Forkhead-associated protein; SPTR: C4ZH62 Putative uncharacterized protein; PFAM: FHA domain.
    
 0.597
Your Current Organism:
Syntrophothermus lipocalidus
NCBI taxonomy Id: 643648
Other names: S. lipocalidus DSM 12680, Syntrophothermus lipocalidus DSM 12680, Syntrophothermus lipocalidus TGB-C1, Syntrophothermus lipocalidus str. DSM 12680, Syntrophothermus lipocalidus strain DSM 12680
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