STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Slip_0550Haloacid dehalogenase domain protein hydrolase; COGs: COG1011 hydrolase (HAD superfamily); InterPro IPR005834:IPR005833; KEGG: swo:Swol_2046 hypothetical protein; PFAM: Haloacid dehalogenase domain protein hydrolase; SPTR: Q0AVB4 Putative uncharacterized protein; PFAM: haloacid dehalogenase-like hydrolase. (235 aa)    
Predicted Functional Partners:
Slip_0239
YbaK/prolyl-tRNA synthetase associated region; COGs: COG2606 conserved hypothetical protein; InterPro IPR007214; KEGG: cdl:CDR20291_0909 putative regulatory protein; PFAM: YbaK/prolyl-tRNA synthetase associated region; SPTR: C1PCK8 YbaK/prolyl-tRNA synthetase associated region; PFAM: YbaK / prolyl-tRNA synthetases associated domain.
      0.815
Slip_1721
Phosphoesterase PA-phosphatase related protein; COGs: COG1238 membrane protein; InterPro IPR015414:IPR000326:IPR016118; KEGG: drm:Dred_2300 hypothetical protein; PFAM: phosphoesterase PA-phosphatase related; SNARE associated Golgi protein; SMART: phosphoesterase PA-phosphatase related; SPTR: A4J6V7 Putative uncharacterized protein; PFAM: PAP2 superfamily; SNARE associated Golgi protein.
  
   0.550
guaA
GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP.
  
  
 0.483
Slip_0639
Transcriptional regulator, GntR family; COGs: COG2188 Transcriptional regulators; InterPro IPR000524:IPR016040:IPR011991:IPR006037; KEGG: dhd:Dhaf_1338 transcriptional regulator, GntR family; PFAM: TrkA-C domain protein; regulatory protein GntR HTH; SMART: regulatory protein GntR HTH; SPTR: Q24Q77 Putative uncharacterized protein; PFAM: Bacterial regulatory proteins, gntR family; TrkA-C domain.
  
  
 0.480
Slip_0551
COGs: COG0778 Nitroreductase; InterPro IPR000415; KEGG: swo:Swol_2164 nitroreductase; PFAM: nitroreductase; SPTR: Q0AUZ9 Nitroreductase; PFAM: Nitroreductase family.
  
    0.477
Slip_1044
KEGG: swo:Swol_1259 hypothetical protein; SPTR: Q0AXI6 Putative uncharacterized protein; PFAM: Heavy-metal-associated domain.
  
     0.465
Slip_1701
COGs: COG0469 Pyruvate kinase; InterProIPR015793:IPR015794:IPR008279:IPR015813:IPR 015795:IPR011037:IPR018209:IPR001697; KEGG: swo:Swol_2040 pyruvate kinase; PFAM: Pyruvate kinase barrel; Pyruvate kinase alpha/beta; PEP-utilising protein mobile region; SPTR: Q0AVC0 Pyruvate kinase; TIGRFAM: pyruvate kinase; PFAM: Pyruvate kinase, barrel domain; PEP-utilising enzyme, mobile domain; Pyruvate kinase, alpha/beta domain; TIGRFAM: pyruvate kinase; Belongs to the pyruvate kinase family.
  
  
 0.440
hisI
phosphoribosyl-ATP diphosphatase; COGs: COG0139 Phosphoribosyl-AMP cyclohydrolase; InterPro IPR008179:IPR002496; KEGG: swo:Swol_1764 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; PFAM: phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; SPTR: Q0AW42 Phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP pyrophosphatase; TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: Phosphoribosyl-ATP pyrophosphohydrolase; Phosphoribosyl-AMP cyclohydrolase; TIGRFAM: phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; [...]
     
 0.432
Slip_1475
KEGG: swo:Swol_1336 hypothetical protein; SPTR: Q0AXB0 Putative uncharacterized protein; PFAM: Protein of unknown function (DUF3189).
  
     0.425
Slip_0734
Homocysteine S-methyltransferase; COGs: COG1410 Methionine synthase I cobalamin-binding domain; InterProIPR003726:IPR011005:IPR006158:IPR003759:IPR 017215:IPR000489; KEGG: swo:Swol_1442 5-methyltetrahydrofolate-homocysteine methyltransferase, truncation; PFAM: homocysteine S-methyltransferase; dihydropteroate synthase DHPS; Methionine synthase B12-binding module cap domain protein; cobalamin B12-binding domain protein; SPTR: Q0AX05 Methionine synthase (B12-dependent); PFAM: Pterin binding enzyme; B12 binding domain; Homocysteine S-methyltransferase; TIGRFAM: methyltransferase cognate c [...]
  
    0.420
Your Current Organism:
Syntrophothermus lipocalidus
NCBI taxonomy Id: 643648
Other names: S. lipocalidus DSM 12680, Syntrophothermus lipocalidus DSM 12680, Syntrophothermus lipocalidus TGB-C1, Syntrophothermus lipocalidus str. DSM 12680, Syntrophothermus lipocalidus strain DSM 12680
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