Slip_0778 protein (Syntrophothermus lipocalidus)

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Slip_0778

Phenylacetate--CoA ligase; Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA). (432 aa)

Predicted Functional Partners:

Slip_1995

0.975

Slip_0779

0.960

Slip_0776

0.622

Slip_0777

0.592

Slip_1382

0.549

Slip_1381

0.519

Slip_0780

0.492

Slip_0164

0.414

Slip_2358

0.408

Your Current Organism:

Syntrophothermus lipocalidus

NCBI taxonomy Id: 643648
Other names: S. lipocalidus DSM 12680, Syntrophothermus lipocalidus DSM 12680, Syntrophothermus lipocalidus TGB-C1, Syntrophothermus lipocalidus str. DSM 12680, Syntrophothermus lipocalidus strain DSM 12680

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
Slip_0164	Slip_0778	NAD-dependent epimerase/dehydratase; COGs: COG0451 Nucleoside-diphosphate-sugar epimerase; InterProIPR000888:IPR016040:IPR011051:IPR014710:IPR 001509; KEGG: drm:Dred_3032 NAD-dependent epimerase/dehydratase; PFAM: NAD-dependent epimerase/dehydratase; SPTR: A4J8Y2 NAD-dependent epimerase/dehydratase; PFAM: NAD dependent epimerase/dehydratase family; WxcM-like, C-terminal.	Phenylacetate--CoA ligase; Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).	0.414
Slip_0776	Slip_0777	UBA/THIF-type NAD/FAD binding protein; COGs: COG1179 Dinucleotide-utilizing protein involved in molybdopterin and thiamine biosynthesis family 1; InterPro IPR009036:IPR016040:IPR000594; KEGG: swo:Swol_0813 hypothetical protein; PFAM: UBA/THIF-type NAD/FAD binding protein; SPTR: C0CPG2 Putative uncharacterized protein; manually curated; PFAM: ThiF family.	thiamineS protein; InterPro IPR016155; KEGG: sfu:Sfum_2286 thiamineS protein; SPTR: A0LKL6 ThiamineS protein; PFAM: ThiS family.	0.773
Slip_0776	Slip_0778	UBA/THIF-type NAD/FAD binding protein; COGs: COG1179 Dinucleotide-utilizing protein involved in molybdopterin and thiamine biosynthesis family 1; InterPro IPR009036:IPR016040:IPR000594; KEGG: swo:Swol_0813 hypothetical protein; PFAM: UBA/THIF-type NAD/FAD binding protein; SPTR: C0CPG2 Putative uncharacterized protein; manually curated; PFAM: ThiF family.	Phenylacetate--CoA ligase; Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).	0.622
Slip_0776	Slip_0779	UBA/THIF-type NAD/FAD binding protein; COGs: COG1179 Dinucleotide-utilizing protein involved in molybdopterin and thiamine biosynthesis family 1; InterPro IPR009036:IPR016040:IPR000594; KEGG: swo:Swol_0813 hypothetical protein; PFAM: UBA/THIF-type NAD/FAD binding protein; SPTR: C0CPG2 Putative uncharacterized protein; manually curated; PFAM: ThiF family.	COGs: COG4747 ACT domain-containing protein; InterPro IPR002912; KEGG: swo:Swol_0816 amino acid-binding ACT; PFAM: amino acid-binding ACT domain protein; SPTR: Q0AYR7 ACT domain protein; PFAM: ACT domain.	0.562
Slip_0777	Slip_0776	thiamineS protein; InterPro IPR016155; KEGG: sfu:Sfum_2286 thiamineS protein; SPTR: A0LKL6 ThiamineS protein; PFAM: ThiS family.	UBA/THIF-type NAD/FAD binding protein; COGs: COG1179 Dinucleotide-utilizing protein involved in molybdopterin and thiamine biosynthesis family 1; InterPro IPR009036:IPR016040:IPR000594; KEGG: swo:Swol_0813 hypothetical protein; PFAM: UBA/THIF-type NAD/FAD binding protein; SPTR: C0CPG2 Putative uncharacterized protein; manually curated; PFAM: ThiF family.	0.773
Slip_0777	Slip_0778	thiamineS protein; InterPro IPR016155; KEGG: sfu:Sfum_2286 thiamineS protein; SPTR: A0LKL6 ThiamineS protein; PFAM: ThiS family.	Phenylacetate--CoA ligase; Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).	0.592
Slip_0777	Slip_0779	thiamineS protein; InterPro IPR016155; KEGG: sfu:Sfum_2286 thiamineS protein; SPTR: A0LKL6 ThiamineS protein; PFAM: ThiS family.	COGs: COG4747 ACT domain-containing protein; InterPro IPR002912; KEGG: swo:Swol_0816 amino acid-binding ACT; PFAM: amino acid-binding ACT domain protein; SPTR: Q0AYR7 ACT domain protein; PFAM: ACT domain.	0.562
Slip_0778	Slip_0164	Phenylacetate--CoA ligase; Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).	NAD-dependent epimerase/dehydratase; COGs: COG0451 Nucleoside-diphosphate-sugar epimerase; InterProIPR000888:IPR016040:IPR011051:IPR014710:IPR 001509; KEGG: drm:Dred_3032 NAD-dependent epimerase/dehydratase; PFAM: NAD-dependent epimerase/dehydratase; SPTR: A4J8Y2 NAD-dependent epimerase/dehydratase; PFAM: NAD dependent epimerase/dehydratase family; WxcM-like, C-terminal.	0.414
Slip_0778	Slip_0776	Phenylacetate--CoA ligase; Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).	UBA/THIF-type NAD/FAD binding protein; COGs: COG1179 Dinucleotide-utilizing protein involved in molybdopterin and thiamine biosynthesis family 1; InterPro IPR009036:IPR016040:IPR000594; KEGG: swo:Swol_0813 hypothetical protein; PFAM: UBA/THIF-type NAD/FAD binding protein; SPTR: C0CPG2 Putative uncharacterized protein; manually curated; PFAM: ThiF family.	0.622
Slip_0778	Slip_0777	Phenylacetate--CoA ligase; Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).	thiamineS protein; InterPro IPR016155; KEGG: sfu:Sfum_2286 thiamineS protein; SPTR: A0LKL6 ThiamineS protein; PFAM: ThiS family.	0.592
Slip_0778	Slip_0779	Phenylacetate--CoA ligase; Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).	COGs: COG4747 ACT domain-containing protein; InterPro IPR002912; KEGG: swo:Swol_0816 amino acid-binding ACT; PFAM: amino acid-binding ACT domain protein; SPTR: Q0AYR7 ACT domain protein; PFAM: ACT domain.	0.960
Slip_0778	Slip_0780	Phenylacetate--CoA ligase; Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).	COGs: COG4978 Transcriptional regulator effector-binding domain/component; InterPro IPR011256:IPR010499; KEGG: str:Sterm_3611 transcriptional regulator, MerR family; PFAM: transcription activator effector binding; SPTR: C6PRQ6 Transcriptional regulator, MerR family; PFAM: Bacterial transcription activator, effector binding domain.	0.492
Slip_0778	Slip_1381	Phenylacetate--CoA ligase; Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).	COGs: COG1014 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase gamma subunit; InterPro IPR002869:IPR019752; KEGG: swo:Swol_1195 indolepyruvate oxidoreductase subunit beta; PFAM: Pyruvate/ketoisovalerate oxidoreductase; SPTR: Q0AXQ0 Indolepyruvate oxidoreductase subunit beta 2; PFAM: Pyruvate ferredoxin/flavodoxin oxidoreductase; TIGRFAM: indolepyruvate ferredoxin oxidoreductase, beta subunit.	0.519
Slip_0778	Slip_1382	Phenylacetate--CoA ligase; Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).	Indolepyruvate ferredoxin oxidoreductase, alpha subunit; Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.	0.549
Slip_0778	Slip_1995	Phenylacetate--CoA ligase; Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).	Thioesterase superfamily protein; COGs: COG2050 Uncharacterized protein possibly involved in aromatic compounds catabolism; InterPro IPR003736:IPR006683; KEGG: sfu:Sfum_0232 hypothetical protein; PFAM: thioesterase superfamily protein; SPTR: A0LET1 Uncharacterized domain 1; PFAM: Thioesterase superfamily; TIGRFAM: uncharacterized domain 1; phenylacetic acid degradation protein PaaD.	0.975
Slip_0778	Slip_2358	Phenylacetate--CoA ligase; Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).	ABC transporter related protein; COGs: COG0410 ABC-type branched-chain amino acid transport systems ATPase component; InterPro IPR003593:IPR003439:IPR017871; KEGG: swo:Swol_2552 branched-chain amino acid ABC transporter ATP-binding protein; PFAM: ABC transporter related; SMART: AAA ATPase; SPTR: Q0ATW5 Branched-chain amino acid ABC transporter (ATP-binding protein); PFAM: ABC transporter.	0.408
Slip_0779	Slip_0776	COGs: COG4747 ACT domain-containing protein; InterPro IPR002912; KEGG: swo:Swol_0816 amino acid-binding ACT; PFAM: amino acid-binding ACT domain protein; SPTR: Q0AYR7 ACT domain protein; PFAM: ACT domain.	UBA/THIF-type NAD/FAD binding protein; COGs: COG1179 Dinucleotide-utilizing protein involved in molybdopterin and thiamine biosynthesis family 1; InterPro IPR009036:IPR016040:IPR000594; KEGG: swo:Swol_0813 hypothetical protein; PFAM: UBA/THIF-type NAD/FAD binding protein; SPTR: C0CPG2 Putative uncharacterized protein; manually curated; PFAM: ThiF family.	0.562
Slip_0779	Slip_0777	COGs: COG4747 ACT domain-containing protein; InterPro IPR002912; KEGG: swo:Swol_0816 amino acid-binding ACT; PFAM: amino acid-binding ACT domain protein; SPTR: Q0AYR7 ACT domain protein; PFAM: ACT domain.	thiamineS protein; InterPro IPR016155; KEGG: sfu:Sfum_2286 thiamineS protein; SPTR: A0LKL6 ThiamineS protein; PFAM: ThiS family.	0.562
Slip_0779	Slip_0778	COGs: COG4747 ACT domain-containing protein; InterPro IPR002912; KEGG: swo:Swol_0816 amino acid-binding ACT; PFAM: amino acid-binding ACT domain protein; SPTR: Q0AYR7 ACT domain protein; PFAM: ACT domain.	Phenylacetate--CoA ligase; Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).	0.960
Slip_0779	Slip_0780	COGs: COG4747 ACT domain-containing protein; InterPro IPR002912; KEGG: swo:Swol_0816 amino acid-binding ACT; PFAM: amino acid-binding ACT domain protein; SPTR: Q0AYR7 ACT domain protein; PFAM: ACT domain.	COGs: COG4978 Transcriptional regulator effector-binding domain/component; InterPro IPR011256:IPR010499; KEGG: str:Sterm_3611 transcriptional regulator, MerR family; PFAM: transcription activator effector binding; SPTR: C6PRQ6 Transcriptional regulator, MerR family; PFAM: Bacterial transcription activator, effector binding domain.	0.517

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Network Stats

number of nodes:

8

number of edges:

14

average node degree:

3.5

avg. local clustering coefficient:

0.917

expected number of edges:

13

PPI enrichment p-value:

0.462

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:8254

Mixed, incl. Phosphopantetheine, and Wax biosynthesis

4 of 22

2.69

3.79

3.64e-07

CL:8266

Wax biosynthesis, and Polyketide synthase, ketoreductase domain

3 of 6

3.13

3.52

1.65e-06

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-163765

ChREBP activates metabolic gene expression

3 of 18

2.65

2.53

5.88e-05

MAP-199220

Vitamin B5 (pantothenate) metabolism

3 of 22

2.56

2.51

5.88e-05

MAP-75105

Fatty acyl-CoA biosynthesis

3 of 40

2.3

2.16

0.00018

MAP-163685

Integration of energy metabolism

3 of 60

2.13

1.89

0.00044

MAP-8978868

Fatty acid metabolism

3 of 162

1.69

1.16

0.0063

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0596

Phosphopantetheine

4 of 12

2.95

5.03

3.85e-09

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00550

Phosphopantetheine attachment site

4 of 12

2.95

4.6

2.10e-08

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036736

ACP-like superfamily

4 of 12

2.95

4.34

6.02e-08

IPR009081

Phosphopantetheine binding ACP domain

4 of 12

2.95

4.34

6.02e-08

IPR013968

Polyketide synthase, ketoreductase domain

3 of 8

3.0

3.1

7.79e-06

IPR006162

Phosphopantetheine attachment site

2 of 6

2.95

1.51

0.0035

IPR036291

NAD(P)-binding domain superfamily

3 of 210

1.58

0.74

0.0434

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00822

This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group.

2 of 7

2.88

1.59

0.0025

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