STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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cheBResponse regulator receiver modulated CheB methylesterase; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family. (359 aa)    
Predicted Functional Partners:
Slip_0978
CheA signal transduction histidine kinase; COGs: COG0643 Chemotaxis protein histidine kinase and related kinase; InterProIPR008207:IPR003594:IPR002545:IPR010808:IPR 004105:IPR004358:IPR009082:IPR005467; KEGG: swo:Swol_0874 putative CheA signal transduction histidine kinases; PFAM: CheW domain protein; ATP-binding region ATPase domain protein; Signal transducing histidine kinase homodimeric; P2 response regulator binding domain protein; Hpt domain protein; SMART: CheW domain protein; Hpt domain protein; ATP-binding region ATPase domain protein; SPTR: Q0AYL2 Putative CheA signal transduc [...]
 0.999
Slip_1728
CheA signal transduction histidine kinase; COGs: COG0643 Chemotaxis protein histidine kinase and related kinase; InterProIPR005467:IPR002545:IPR008207:IPR004358:IPR 004105:IPR003594:IPR009082; KEGG: swo:Swol_1455 putative CheA signal transduction histidine kinases; PFAM: ATP-binding region ATPase domain protein; Signal transducing histidine kinase homodimeric; Hpt domain protein; CheW domain protein; SMART: ATP-binding region ATPase domain protein; Hpt domain protein; CheW domain protein; SPTR: Q0AWZ2 CheA signal transduction histidine kinase; PFAM: CheW-like domain; Histidine kinase-, [...]
 0.998
Slip_1419
MCP methyltransferase, CheR-type; COGs: COG1352 Methylase of chemotaxis methyl-accepting protein; InterPro IPR000780; KEGG: swo:Swol_0695 protein-glutamate O-methyltransferase; PFAM: MCP methyltransferase CheR-type; PRIAM: Protein-glutamate O-methyltransferase; SMART: MCP methyltransferase CheR-type; SPTR: Q0AZ35 MCP methyltransferase, CheR-type; PFAM: CheR methyltransferase, SAM binding domain; CheR methyltransferase, all-alpha domain.
  
 0.993
Slip_0966
COGs: COG1776 Chemotaxis protein CheC inhibitor of MCP methylation; InterPro IPR007597:IPR001543:IPR001172:IPR012826; KEGG: swo:Swol_0862 CheC, inhibitor of MCP methylation; PFAM: surface presentation of antigens (SPOA) protein; CheC domain protein; SPTR: Q0AYM4 CheC, inhibitor of MCP methylation; TIGRFAM: flagellar motor switch protein FliN; PFAM: Surface presentation of antigens (SPOA); CheC-like family; TIGRFAM: flagellar motor switch protein FliN.
  
  
 0.992
Slip_1726
MCP methyltransferase, CheR-type; COGs: COG1352 Methylase of chemotaxis methyl-accepting protein; InterPro IPR000780; KEGG: swo:Swol_1457 protein-glutamate O-methyltransferase; PFAM: MCP methyltransferase CheR-type; PRIAM: Protein-glutamate O-methyltransferase; SMART: MCP methyltransferase CheR-type; SPTR: Q0AWZ0 MCP methyltransferase, CheR-type; PFAM: CheR methyltransferase, SAM binding domain; CheR methyltransferase, all-alpha domain.
  
 0.992
Slip_0979
CheW protein; COGs: COG0835 Chemotaxis signal transduction protein; InterPro IPR002545; KEGG: swo:Swol_0875 CheW protein; PFAM: CheW domain protein; SMART: CheW domain protein; SPTR: Q0AYL1 CheW protein; PFAM: CheW-like domain.
 
 
 0.989
Slip_1035
COGs: COG0840 Methyl-accepting chemotaxis protein; InterPro IPR003660:IPR004089; KEGG: cac:CAC0443 methyl-accepting chemotaxis protein; PFAM: chemotaxis sensory transducer; histidine kinase HAMP region domain protein; SMART: chemotaxis sensory transducer; histidine kinase HAMP region domain protein; SPTR: C4ILN2 Methyl-accepting chemotaxis protein; PFAM: Methyl-accepting chemotaxis protein (MCP) signaling domain.
 0.984
Slip_1250
Methyl-accepting chemotaxis sensory transducer with Cache sensor; COGs: COG0840 Methyl-accepting chemotaxis protein; InterPro IPR004089:IPR003660:IPR004010:IPR004090; KEGG: hor:Hore_04800 methyl-accepting chemotaxis sensory transducer; PFAM: chemotaxis sensory transducer; histidine kinase HAMP region domain protein; Cache domain protein; SMART: chemotaxis sensory transducer; histidine kinase HAMP region domain protein; SPTR: B8D211 Methyl-accepting chemotaxis sensory transducer; PFAM: HAMP domain; Cache domain; Methyl-accepting chemotaxis protein (MCP) signaling domain.
 0.984
Slip_1365
COGs: COG0840 Methyl-accepting chemotaxis protein; InterPro IPR004089:IPR003660:IPR004090; KEGG: swo:Swol_0927 putative methyl-accepting chemotaxis sensory transducer; PFAM: chemotaxis sensory transducer; histidine kinase HAMP region domain protein; SMART: chemotaxis sensory transducer; histidine kinase HAMP region domain protein; SPTR: Q0AYG1 Putative methyl-accepting chemotaxis sensory transducer; PFAM: HAMP domain; Methyl-accepting chemotaxis protein (MCP) signaling domain.
 0.984
Slip_1732
COGs: COG0840 Methyl-accepting chemotaxis protein; InterPro IPR004089; KEGG: swo:Swol_1451 putative methyl-accepting chemotaxis sensory transducer; PFAM: chemotaxis sensory transducer; SMART: chemotaxis sensory transducer; SPTR: Q0AWZ6 Putative methyl-accepting chemotaxis sensory transducer; PFAM: Methyl-accepting chemotaxis protein (MCP) signaling domain.
 
 0.984
Your Current Organism:
Syntrophothermus lipocalidus
NCBI taxonomy Id: 643648
Other names: S. lipocalidus DSM 12680, Syntrophothermus lipocalidus DSM 12680, Syntrophothermus lipocalidus TGB-C1, Syntrophothermus lipocalidus str. DSM 12680, Syntrophothermus lipocalidus strain DSM 12680
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