STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Slip_1110Peptidase M24; COGs: COG0006 Xaa-Pro aminopeptidase; InterPro IPR000587:IPR000994; KEGG: drm:Dred_1765 creatinase; PFAM: peptidase M24; creatinase; SPTR: A4J5D7 Creatinase; PFAM: Metallopeptidase family M24; Creatinase/Prolidase N-terminal domain. (395 aa)    
Predicted Functional Partners:
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
   
   0.731
Slip_0447
Peptidase T-like protein; COGs: COG2195 Di- and tripeptidase; InterPro IPR010162:IPR001261:IPR011650:IPR002933; KEGG: swo:Swol_0595 tripeptidase; PFAM: peptidase M20; peptidase dimerisation domain protein; SPTR: Q0AZD0 Tripeptidase; TIGRFAM: peptidase T-like protein; PFAM: Peptidase family M20/M25/M40; Peptidase dimerisation domain; TIGRFAM: peptidase T-like protein.
 
 
 0.653
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
  
 0.609
nadE-2
NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
  
 
  0.532
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
  
 
 0.516
Slip_0289
KEGG: drm:Dred_1766 hypothetical protein; SPTR: A4J5D8 Conserved hypothetical cytosolic protein.
 
     0.502
Slip_1109
Protein of unknown function DUF35; COGs: COG1545 nucleic-acid-binding protein containing a Zn-ribbon; InterPro IPR002878; KEGG: dal:Dalk_3386 protein of unknown function DUF35; PFAM: protein of unknown function DUF35; SPTR: B8FLC9 Putative uncharacterized protein; PFAM: Rubredoxin-like zinc ribbon domain (DUF35_N); DUF35 OB-fold domain.
       0.495
metG
methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
   
 
 0.479
Slip_2292
CMP/dCMP deaminase zinc-binding protein; COGs: COG2131 Deoxycytidylate deaminase; InterPro IPR016193:IPR016473:IPR002125:IPR016192; KEGG: swo:Swol_2391 putative ComE operon protein 2; PFAM: CMP/dCMP deaminase zinc-binding; SPTR: Q0AUC4 Putative ComE operon protein 2; PFAM: Cytidine and deoxycytidylate deaminase zinc-binding region.
  
    0.473
Slip_1386
DnaB domain protein helicase domain protein; COGs: COG0305 Replicative DNA helicase; InterPro IPR007693:IPR007694:IPR016136; KEGG: swo:Swol_1201 replicative DNA helicase-like protein; PFAM: DnaB domain protein helicase domain protein; SPTR: Q0AXP4 Primary replicative DNA helicase; PFAM: DnaB-like helicase N terminal domain; DnaB-like helicase C terminal domain.
  
  
 0.450
Your Current Organism:
Syntrophothermus lipocalidus
NCBI taxonomy Id: 643648
Other names: S. lipocalidus DSM 12680, Syntrophothermus lipocalidus DSM 12680, Syntrophothermus lipocalidus TGB-C1, Syntrophothermus lipocalidus str. DSM 12680, Syntrophothermus lipocalidus strain DSM 12680
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