STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Cooccurrence
Coexpression
Experiments
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[Homology]
Score
Slip_1361Diguanylate cyclase; COGs: COG0517 FOG: CBS domain; InterPro IPR000160:IPR000644:IPR013785; KEGG: drm:Dred_1016 diguanylate cyclase; PFAM: CBS domain containing protein; GGDEF domain containing protein; SMART: GGDEF domain containing protein; CBS domain containing protein; SPTR: A4J398 Diguanylate cyclase; TIGRFAM: diguanylate cyclase; PFAM: CBS domain; GGDEF domain; TIGRFAM: diguanylate cyclase (GGDEF) domain. (289 aa)    
Predicted Functional Partners:
guaA
GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP.
 
 
 0.971
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
 
  
 
0.950
surE
Stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
   
  0.917
Slip_2120
COGs: COG0518 GMP synthase - Glutamine amidotransferase domain; InterPro IPR017926:IPR000991; KEGG: adg:Adeg_1887 glutamine amidotransferase class-I; PFAM: glutamine amidotransferase class-I; SPTR: C9R9I8 Glutamine amidotransferase class-I; PFAM: Glutamine amidotransferase class-I.
  
 
 0.912
purH
Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; COGs: COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful); InterPro IPR002695:IPR013982:IPR011607; KEGG: swo:Swol_1775 phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: AICARFT/IMPCHase bienzyme formylation region; MGS domain protein; PRIAM: Phosphoribosylaminoimidazolecarboxamide formyltransferase; SMART: AICARFT/IMPCHase bienzyme formylation region; SPTR: Q0AW31 Bifunctional purine biosynthesis protein purH; TIGRFAM: phosphoribosylaminoimidazolecarbox [...]
  
 
 0.911
Slip_0589
COGs: COG0634 Hypoxanthine-guanine phosphoribosyltransferase; InterPro IPR005904:IPR000836; KEGG: dae:Dtox_0723 hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; PRIAM: Hypoxanthine phosphoribosyltransferase; SPTR: C8W1J2 Hypoxanthine phosphoribosyltransferase; TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: Phosphoribosyl transferase domain; TIGRFAM: hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
    
  0.906
Slip_1360
KEGG: mta:Moth_0522 hypothetical protein; SPTR: Q2RL37 Putative uncharacterized protein.
 
     0.906
Slip_2049
Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
    
  0.905
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
     
 0.905
Slip_0498
Diguanylate cyclase and metal dependent phosphohydrolase; COGs: COG2206 HD-GYP domain; InterProIPR000014:IPR000160:IPR013767:IPR003018:IPR 013656:IPR006674:IPR000700:IPR001610:IPR003607; KEGG: drm:Dred_1552 diguanylate cyclase with PAS/PAC sensor; PFAM: GGDEF domain containing protein; PAS fold domain protein; GAF domain protein; PAS fold-4 domain protein; metal-dependent phosphohydrolase HD sub domain; SMART: GGDEF domain containing protein; PAC repeat-containing protein; PAS domain containing protein; GAF domain protein; metal-dependent phosphohydrolase HD region; SPTR: A4J4S7 Diguan [...]
 
 
 0.739
Your Current Organism:
Syntrophothermus lipocalidus
NCBI taxonomy Id: 643648
Other names: S. lipocalidus DSM 12680, Syntrophothermus lipocalidus DSM 12680, Syntrophothermus lipocalidus TGB-C1, Syntrophothermus lipocalidus str. DSM 12680, Syntrophothermus lipocalidus strain DSM 12680
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