STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
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Experiments
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Textmining
[Homology]
Score
hemCPorphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (316 aa)    
Predicted Functional Partners:
Slip_1424
Porphobilinogen synthase; COGs: COG0113 Delta-aminolevulinic acid dehydratase; InterPro IPR001731:IPR013785; KEGG: swo:Swol_0690 delta-aminolevulinic acid dehydratase; PFAM: delta-aminolevulinic acid dehydratase; PRIAM: Porphobilinogen synthase; SPTR: Q0AZ40 Delta-aminolevulinic acid dehydratase; PFAM: Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.
 
 0.999
Slip_1426
uroporphyrin-III C-methyltransferase; COGs: COG0007 Uroporphyrinogen-III methylase; InterProIPR000878:IPR003754:IPR003043:IPR014777:IPR 014776:IPR006366; KEGG: swo:Swol_0687 hypothetical protein; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Uroporphyrinogen III synthase HEM4; SPTR: Q0AZ42 Uroporphyrinogen-III synthase / uroporphyrinogen-III C-methyltransferase; TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; Uroporphyrinogen-III synthase HemD; TIGRFAM: uroporphyrin-III C-methyltransferase.
 0.999
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
  
 0.998
hemL
Glutamate-1-semialdehyde-2,1-aminomutase; COGs: COG0001 Glutamate-1-semialdehyde aminotransferase; InterPro IPR015424:IPR005814:IPR015421:IPR004639; KEGG: swo:Swol_0694 glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III; SPTR: Q0AZ36 Glutamate-1-semialdehyde 2,1-aminomutase; TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: Aminotransferase class-III; TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase.
  
 0.982
Slip_1429
COGs: COG1648 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain); InterPro IPR016040:IPR006367; KEGG: swo:Swol_0683 precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase; SPTR: Q0AZ44 Precorrin-2 dehydrogenase; TIGRFAM: siroheme synthase; TIGRFAM: siroheme synthase, N-terminal domain.
  
 0.976
Slip_0923
COGs: COG2875 Precorrin-4 methylase; InterProIPR000878:IPR003043:IPR014777:IPR014776:IPR 006362; KEGG: hmo:HM1_2389 precorrin-4 C11-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; PRIAM: Precorrin-4 C(11)-methyltransferase; SPTR: C5RMQ3 Precorrin-4 C11-methyltransferase; TIGRFAM: precorrin-4 C11-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-4 C11-methyltransferase.
   
 0.919
Slip_0920
COGs: COG2099 Precorrin-6x reductase; InterPro IPR003723; KEGG: dae:Dtox_1297 precorrin-6x reductase; PFAM: Precorrin-6x reductase CbiJ/CobK; SPTR: A1HPX1 Precorrin-6x reductase; TIGRFAM: precorrin-6x reductase; PFAM: Precorrin-6x reductase CbiJ/CobK; TIGRFAM: precorrin-6x reductase.
    
 0.857
tatA-2
Sec-independent translocation protein mttA/Hcf106; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
  
    0.768
Slip_1425
Radical SAM domain protein; COGs: COG0535 Fe-S oxidoreductase; InterPro IPR007197:IPR017200; KEGG: swo:Swol_0688 metallo cofactor biosynthesis protein; PFAM: Radical SAM domain protein; SPTR: Q0AZ41 Metallo cofactor biosynthesis protein; PFAM: Radical SAM superfamily.
     
 0.761
Slip_0318
COGs: COG0407 Uroporphyrinogen-III decarboxylase; InterPro IPR000257; KEGG: swo:Swol_0417 uroporphyrinogen decarboxylase; PFAM: Uroporphyrinogen decarboxylase (URO-D); SPTR: Q0AZU9 Uroporphyrinogen decarboxylase; PFAM: Uroporphyrinogen decarboxylase (URO-D); TIGRFAM: methyltransferase, MtaA/CmuA family; Belongs to the uroporphyrinogen decarboxylase family.
 
 
 0.685
Your Current Organism:
Syntrophothermus lipocalidus
NCBI taxonomy Id: 643648
Other names: S. lipocalidus DSM 12680, Syntrophothermus lipocalidus DSM 12680, Syntrophothermus lipocalidus TGB-C1, Syntrophothermus lipocalidus str. DSM 12680, Syntrophothermus lipocalidus strain DSM 12680
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