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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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fdhD-2Formate dehydrogenase family accessory protein FdhD; Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Belongs to the FdhD family. (261 aa)    
Predicted Functional Partners:
mobA
Molybdenum cofactor guanylyltransferase; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.
 
 
 0.942
Slip_1032
Formate dehydrogenase, alpha subunit; COGs: COG3383 Uncharacterized anaerobic dehydrogenase; InterPro IPR006656:IPR006657:IPR006478:IPR009010; KEGG: swo:Swol_0786 formate dehydrogenase alpha subunit; PFAM: molybdopterin oxidoreductase; molydopterin dinucleotide-binding region; SPTR: Q0AYU7 Formate dehydrogenase alpha subunit; TIGRFAM: formate dehydrogenase, alpha subunit; PFAM: Molybdopterin oxidoreductase; Molydopterin dinucleotide binding domain; TIGRFAM: formate dehydrogenase, alpha subunit, archaeal-type; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
 
 0.859
Slip_1031
Molybdopterin oxidoreductase; COGs: COG3383 Uncharacterized anaerobic dehydrogenase; InterProIPR017900:IPR006655:IPR000283:IPR001041:IPR 019574:IPR001450:IPR006963:IPR006656:IPR017896; KEGG: swo:Swol_0785 NADH dehydrogenase I chain G; PFAM: molybdopterin oxidoreductase; NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding; ferredoxin; 4Fe-4S ferredoxin iron-sulfur binding domain protein; molybdopterin oxidoreductase Fe4S4 region; SPTR: Q0AYU8 NADH dehydrogenase I chain G; PFAM: 2Fe-2S iron-sulfur cluster binding domain; Molybdopterin oxidoreductase; NADH-ubiquinone oxidoredu [...]
 
 
 0.731
moaA
Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate.
 
  
 0.708
Slip_2098
NADH dehydrogenase (quinone); COGs: COG1894 NADH:ubiquinone oxidoreductase NADH-binding (51 kD) subunit; InterProIPR012336:IPR012335:IPR017900:IPR001949:IPR 017896:IPR011538:IPR019554:IPR019575:IPR001450; KEGG: swo:Swol_1701 NADH dehydrogenase (quinone); PFAM: Respiratory-chain NADH dehydrogenase domain 51 kDa subunit; Soluble ligand binding domain; NADH ubiquinone oxidoreductase, F subunit, iron sulphur binding; 4Fe-4S ferredoxin iron-sulfur binding domain protein; PRIAM: NADH dehydrogenase (quinone); SPTR: Q0AWA5 NADH dehydrogenase (Quinone); PFAM: NADH-ubiquinone oxidoreductase-F ir [...]
  
  
 0.673
Slip_1664
COGs: COG1466 DNA polymerase III delta subunit; InterPro IPR010372:IPR008921:IPR005790; KEGG: swo:Swol_1588 DNA polymerase III delta subunit-like protein; PFAM: DNA polymerase III delta; SPTR: Q0AWL4 DNA polymerase III, delta subunit; TIGRFAM: DNA polymerase III, delta subunit; PFAM: DNA polymerase III, delta subunit; TIGRFAM: DNA polymerase III, delta subunit.
       0.658
Slip_1662
Copper-translocating P-type ATPase; COGs: COG2217 Cation transport ATPase; InterProIPR006121:IPR001757:IPR001756:IPR008250:IPR 005834:IPR018303:IPR017969:IPR000150:IPR006403:IPR006416; KEGG: drm:Dred_2982 heavy metal translocating P-type ATPase; PFAM: E1-E2 ATPase-associated domain protein; Heavy metal transport/detoxification protein; Haloacid dehalogenase domain protein hydrolase; SPTR: A4J8T2 Heavy metal translocating P-type ATPase; TIGRFAM: copper-translocating P-type ATPase; heavy metal translocating P-type ATPase; ATPase, P-type (transporting), HAD superfamily, subfamily IC; PFAM [...]
  
    0.650
fdhD
Formate dehydrogenase family accessory protein FdhD; Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Belongs to the FdhD family.
  
  
 
0.553
Slip_1434
Formate dehydrogenase, alpha subunit; COGs: COG3383 Uncharacterized anaerobic dehydrogenase; Contains selenocysteine; InterProIPR009010:IPR017909:IPR006963:IPR006656:IPR 006657:IPR006655:IPR006443:IPR006311; KEGG: swo:Swol_0799 formate dehydrogenase; PFAM: molydopterin dinucleotide-binding region; molybdopterin oxidoreductase; molybdopterin oxidoreductase Fe4S4 region; PRIAM: Nitrate reductase; SPTR: Q0AYT4 Formate dehydrogenase alpha subunit; TIGRFAM: formate dehydrogenase, alpha subunit; manually curated; PFAM: Molybdopterin oxidoreductase; Molydopterin dinucleotide binding domain; M [...]
 
  
 0.551
Slip_0543
Hydrogenase, Fe-only; COGs: COG4624 Iron only hydrogenase large subunit C-terminal domain; InterProIPR013352:IPR017900:IPR003149:IPR009016:IPR 001041:IPR019574:IPR001450:IPR004108:IPR017896; KEGG: swo:Swol_2436 (Fe) hydrogenase, large subunit HymC, putative; PFAM: hydrogenase large subunit domain protein; ferredoxin; NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding; 4Fe-4S ferredoxin iron-sulfur binding domain protein; iron hydrogenase small subunit; SPTR: Q0AU79 (Fe) hydrogenase, large subunit HymC, putative; TIGRFAM: hydrogenase, Fe-only; PFAM: Iron only hydrogenase la [...]
  
 
 0.496
Your Current Organism:
Syntrophothermus lipocalidus
NCBI taxonomy Id: 643648
Other names: S. lipocalidus DSM 12680, Syntrophothermus lipocalidus DSM 12680, Syntrophothermus lipocalidus TGB-C1, Syntrophothermus lipocalidus str. DSM 12680, Syntrophothermus lipocalidus strain DSM 12680
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