STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
Slip_1856Protein of unknown function UPF0052 and CofD; Required for morphogenesis under gluconeogenic growth conditions; Belongs to the gluconeogenesis factor family. (330 aa)    
Predicted Functional Partners:
Slip_1857
Conserved hypothetical protein; Displays ATPase and GTPase activities.
  
  
 0.967
whiA
Protein of unknown function DUF199; Involved in cell division and chromosome segregation.
 
  
 0.936
Slip_1854
COGs: COG1508 DNA-directed RNA polymerase specialized sigma subunit sigma54 homolog; InterPro IPR000394:IPR007046:IPR007634; KEGG: swo:Swol_0265 sigma-54 (RpoN); PFAM: sigma-54 DNA-binding domain protein; sigma-54 factor core-binding region; sigma-54 factor; SPTR: Q0B091 Sigma-54 (RpoN); TIGRFAM: RNA polymerase sigma-54 factor, RpoN; PFAM: Sigma-54 factor, Activator interacting domain (AID); Sigma-54 factor, core binding domain; Sigma-54, DNA binding domain; TIGRFAM: RNA polymerase sigma-54 factor.
       0.632
Slip_1859
ROK family protein; COGs: COG1940 Transcriptional regulator/sugar kinase; InterPro IPR000600; KEGG: hor:Hore_16050 glucokinase; PFAM: ROK family protein; SPTR: B8CYI5 Glucokinase; PFAM: ROK family; TIGRFAM: ROK family protein (putative glucokinase).
       0.585
Slip_1861
COGs: COG0561 hydrolase of the HAD superfamily; InterPro IPR000150:IPR006379:IPR013200; KEGG: adg:Adeg_1822 Cof-like hydrolase; PFAM: Haloacid dehalogenase domain protein hydrolase type 3; SPTR: C9R9C9 Cof-like hydrolase; TIGRFAM: Cof-like hydrolase; HAD-superfamily hydrolase, subfamily IIB; PFAM: haloacid dehalogenase-like hydrolase; TIGRFAM: Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; HAD-superfamily hydrolase, subfamily IIB.
       0.581
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
   
   0.550
Slip_1858
Bifunctional phosphoglucose/phosphomannose isomerase; COGs: COG0166 Glucose-6-phosphate isomerase; InterPro IPR011857:IPR001347:IPR019490; KEGG: swo:Swol_0260 bifunctional phosphoglucose/phosphomannose isomerase; PFAM: Bifunctional glucose-6-phosphate/mannose-6-phosphate isomerase-like; sugar isomerase (SIS); PRIAM: Mannose-6-phosphate isomerase; SPTR: Q0B095 Mannose-6-phosphate isomerase / glucose-6-phosphate isomerase; TIGRFAM: bifunctional phosphoglucose/phosphomannose isomerase; PFAM: Bacterial phospho-glucose isomerase C-terminal region; SIS domain; TIGRFAM: bifunctional phosphogl [...]
     
 0.545
Slip_1853
Transcriptional regulator, DeoR family; COGs: COG2390 Transcriptional regulator contains sigma factor-related N-terminal domain; InterPro IPR007324; KEGG: swo:Swol_0271 transcriptional regulator; PFAM: putative sugar-binding domain protein; SPTR: Q0B085 Transcriptional regulator; PFAM: HTH domain; Putative sugar-binding domain.
 
   
 0.519
Slip_0865
COGs: COG0631 Serine/threonine protein phosphatase; InterPro IPR001932:IPR014045; KEGG: swo:Swol_1226 serine/threonine phosphatase; PFAM: Protein phosphatase 2C-like; SMART: protein phosphatase 2C domain protein; SPTR: Q0AXL9 Serine/threonine phosphatase; PFAM: Protein phosphatase 2C.
   
  
 0.500
Slip_1320
COGs: COG0631 Serine/threonine protein phosphatase; InterPro IPR001932:IPR014045; KEGG: dae:Dtox_2307 protein serine/threonine phosphatase; PFAM: Protein phosphatase 2C-like; SMART: protein phosphatase 2C domain protein; SPTR: C8VZZ2 Protein serine/threonine phosphatase; PFAM: Protein phosphatase 2C.
   
  
 0.500
Your Current Organism:
Syntrophothermus lipocalidus
NCBI taxonomy Id: 643648
Other names: S. lipocalidus DSM 12680, Syntrophothermus lipocalidus DSM 12680, Syntrophothermus lipocalidus TGB-C1, Syntrophothermus lipocalidus str. DSM 12680, Syntrophothermus lipocalidus strain DSM 12680
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