STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Slip_2373KEGG: aac:Aaci_2938 hypothetical protein; SPTR: C5VPU6 Putative uncharacterized protein. (166 aa)    
Predicted Functional Partners:
scpA
Chromosome segregation and condensation protein ScpA; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves.
  
 
 0.886
Slip_2372
Peptidase M23; COGs: COG0739 Membrane protein related to metalloendopeptidase; InterPro IPR011055:IPR016047; KEGG: swo:Swol_2565 metalloendopeptidase-like membrane protein; PFAM: Peptidase M23; SPTR: Q0ATV2 Metalloendopeptidase-like membrane protein; PFAM: Peptidase family M23.
       0.819
Slip_2371
Protein of unknown function DUF583; COGs: COG1664 Integral membrane protein CcmA involved in cell shape determination; InterPro IPR007607; KEGG: swo:Swol_2564 hypothetical protein; PFAM: protein of unknown function DUF583; SPTR: Q0ATV3 Putative uncharacterized protein; PFAM: Protein of unknown function, DUF583.
       0.817
Slip_2370
COGs: COG1926 phosphoribosyltransferase; InterPro IPR000836; KEGG: dau:Daud_2224 phosphoribosyltransferase; PFAM: phosphoribosyltransferase; SPTR: B1I6R3 Phosphoribosyltransferase; PFAM: Phosphoribosyl transferase domain.
       0.694
gyrB
DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
   
 
 0.647
Slip_0189
COGs: COG0123 Deacetylase including yeast histone deacetylase and acetoin utilization protein; InterPro IPR000286; KEGG: pth:PTH_0916 deacetylases; PFAM: histone deacetylase superfamily; SPTR: A5D3S4 Deacetylases; PFAM: Histone deacetylase domain.
   
 0.595
Slip_1075
COGs: COG0123 Deacetylase including yeast histone deacetylase and acetoin utilization protein; InterPro IPR000286; KEGG: mtp:Mthe_1405 histone deacetylase superfamily protein; PFAM: histone deacetylase superfamily; SPTR: A0B906 Histone deacetylase superfamily; PFAM: Histone deacetylase domain.
   
 0.595
Slip_1205
COGs: COG0123 Deacetylase including yeast histone deacetylase and acetoin utilization protein; InterPro IPR000286; KEGG: mtp:Mthe_0463 histone deacetylase superfamily protein; PFAM: histone deacetylase superfamily; SPTR: A0B6D0 Histone deacetylase superfamily; PFAM: Histone deacetylase domain.
   
 0.595
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
 
 0.587
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
  
 
 0.575
Your Current Organism:
Syntrophothermus lipocalidus
NCBI taxonomy Id: 643648
Other names: S. lipocalidus DSM 12680, Syntrophothermus lipocalidus DSM 12680, Syntrophothermus lipocalidus TGB-C1, Syntrophothermus lipocalidus str. DSM 12680, Syntrophothermus lipocalidus strain DSM 12680
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