STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
fumCFumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (466 aa)    
Predicted Functional Partners:
ADR23224.1
COGs: COG1053 Succinate dehydrogenase/fumarate reductase flavoprotein subunit; InterPro IPR003953: IPR004112: IPR013027: IPR011280; KEGG: sli:Slin_5010 succinate dehydrogenase or fumarate reductase, flavoprotein subunit; PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; PRIAM: Succinate dehydrogenase; SPTR: Succinate dehydrogenase flavoprotein subunit; TIGRFAM: succinate dehydrogenase or fumarate reductase, flavoprotein subunit; PFAM: domain; FAD binding domain; TIGRFAM: succinate dehydrogenase or fumarate reductase, flavoprotein subunit, Bacillus subtilis s [...]
 
 0.979
ADR23309.1
COGs: COG0281 Malic enzyme; InterPro IPR012301: IPR012302: IPR002505: IPR012188; KEGG: chu:CHU_0027 malic enzyme; PFAM: malic protein NAD-binding; malic protein domain protein; phosphate acetyl/butaryl transferase; SPTR: NADP-dependent malate dehydrogenase; PFAM: Phosphate acetyl/butaryl transferase; Malic enzyme, NAD binding domain; Malic enzyme, N-terminal domain; TIGRFAM: phosphate acetyltransferase.
  
 
 0.970
ADR20966.1
Malate dehydrogenase (NAD); Catalyzes the reversible oxidation of malate to oxaloacetate.
  
 0.965
ADR23225.1
COGs: COG0479 Succinate dehydrogenase/fumarate reductase Fe-S protein subunit; InterPro IPR001041: IPR004489: IPR017896: IPR006058; KEGG: dfe:Dfer_3971 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; PFAM: ferredoxin; SPTR: Succinate dehydrogenase/fumarate reductase iron-sulfur; TIGRFAM: succinate dehydrogenase and fumarate reductase iron-sulfur protein; PFAM: 2Fe-2S iron-sulfur cluster binding domain; TIGRFAM: succinate dehydrogenase and fumarate reductase iron-sulfur protein.
  
 0.965
ADR23621.1
COGs: COG2225 Malate synthase; InterPro IPR011076: IPR006252: IPR019830; KEGG: sti:Sthe_2906 malate synthase A; PFAM: Malate synthase family protein; PRIAM: Malate synthase; SPTR: Malate synthase; TIGRFAM: malate synthase A; PFAM: Malate synthase; TIGRFAM: malate synthase A.
    
 0.921
ADR20877.1
COGs: COG0372 Citrate synthase; InterPro IPR019810: IPR002020: IPR010953; KEGG: dfe:Dfer_0554 citrate synthase I; PFAM: Citrate synthase; PRIAM: Citrate (Si)-synthase; SPTR: Citrate synthase; TIGRFAM: citrate synthase I; PFAM: Citrate synthase; TIGRFAM: citrate (Si)-synthase, eukaryotic; citrate synthase I (hexameric type); Belongs to the citrate synthase family.
   
 0.918
ADR23223.1
InterPro IPR011138; KEGG: sli:Slin_5011 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; SPTR: Succinate dehydrogenase (Or fumarate reductase) cytochrome b subunit, b558 family; TIGRFAM: succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; TIGRFAM: succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family.
     
  0.900
ADR20822.1
Fumarylacetoacetase; COGs: COG0179 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1 7-dioic acid hydratase (catechol pathway); InterPro IPR015377: IPR002529: IPR005959; KEGG: gfo:GFO_2263 fumarylacetoacetase; PFAM: Domain of unknown function DUF1969; fumarylacetoacetate (FAA) hydrolase; PRIAM: Fumarylacetoacetase; SPTR: Fumarylacetoacetase; TIGRFAM: fumarylacetoacetase; PFAM: Domain of unknown function (DUF1969); Fumarylacetoacetate (FAA) hydrolase family; TIGRFAM: fumarylacetoacetase.
   
 0.840
ADR20611.1
COGs: COG1012 NAD-dependent aldehyde dehydrogenase; InterPro IPR015590; KEGG: hma:rrnB0219 succinate-semialdehyde dehydrogenase; PFAM: Aldehyde Dehydrogenase; SPTR: Succinate-semialdehyde dehydrogenase; PFAM: Aldehyde dehydrogenase family.
   
 0.830
argH
COGs: COG0165 Argininosuccinate lyase; InterPro IPR003031: IPR000362: IPR020557: IPR009049; KEGG: chu:CHU_3088 argininosuccinate lyase; PFAM: fumarate lyase; SPTR: Argininosuccinate lyase; TIGRFAM: argininosuccinate lyase; PFAM: Lyase; TIGRFAM: argininosuccinate lyase.
   
 
 0.825
Your Current Organism:
Marivirga tractuosa
NCBI taxonomy Id: 643867
Other names: Flexibacter tractuosus DSM 4126, Flexibacter tractuosus IFO 15989, M. tractuosa DSM 4126, Marivirga tractuosa DSM 4126, Marivirga tractuosa IFO 15989, Marivirga tractuosa str. DSM 4126, Marivirga tractuosa strain DSM 4126
Server load: low (16%) [HD]