STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
hemCHydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (311 aa)    
Predicted Functional Partners:
ADR21595.1
Porphobilinogen synthase; COGs: COG0113 Delta-aminolevulinic acid dehydratase; InterPro IPR001731; KEGG: sli:Slin_5386 porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; PRIAM: Porphobilinogen synthase; SPTR: Delta-aminolevulinic acid dehydratase; PFAM: Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.
 
 0.994
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
  
 0.992
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 
 0.990
ADR22965.1
COGs: COG0007 Uroporphyrinogen-III methylase; InterPro IPR000878: IPR006366; KEGG: sli:Slin_2052 uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: Uroporphyrin-III C-methyltransferase; TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: uroporphyrin-III C-methyltransferase.
  
 0.989
ADR22532.1
COGs: COG1587 Uroporphyrinogen-III synthase; InterPro IPR003754; KEGG: chu:CHU_0169 uroporphyrinogen-III synthase; PFAM: Uroporphyrinogen III synthase HEM4; SPTR: Possible uroporphyrinogen-III synthase; manually curated; PFAM: Uroporphyrinogen-III synthase HemD.
  
 0.981
hemL
COGs: COG0001 Glutamate-1-semialdehyde aminotransferase; InterPro IPR004639: IPR005814; KEGG: dfe:Dfer_1148 glutamate-1-semialdehyde aminotransferase; PFAM: aminotransferase class-III; SPTR: Glutamate-1-semialdehyde-2,1-aminomutase; TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: Aminotransferase class-III; TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase.
  
 0.939
ADR22746.1
Peptidyl-prolyl cis-trans isomerase cyclophilin type; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.
 
  
 0.911
ADR22747.1
dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.
       0.789
ADR22966.1
COGs: COG1648 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain); InterPro IPR006367; KEGG: chu:CHU_2635 precorrin-2 dehydrogenase; SPTR: Precorrin-2 dehydrogenase; TIGRFAM: siroheme synthase; TIGRFAM: siroheme synthase, N-terminal domain.
 
  
 0.715
ADR22947.1
Scaffold protein Nfu/NifU; COGs: COG0694 Thioredoxin-like protein and domains; InterPro IPR014824: IPR001075; KEGG: dfe:Dfer_4882 nitrogen-fixing NifU domain protein; PFAM: Scaffold protein Nfu/NifU; nitrogen-fixing NifU domain protein; SPTR: NifU domain protein; PFAM: Scaffold protein Nfu/NifU N terminal; NifU-like domain.
 
      0.605
Your Current Organism:
Marivirga tractuosa
NCBI taxonomy Id: 643867
Other names: Flexibacter tractuosus DSM 4126, Flexibacter tractuosus IFO 15989, M. tractuosa DSM 4126, Marivirga tractuosa DSM 4126, Marivirga tractuosa IFO 15989, Marivirga tractuosa str. DSM 4126, Marivirga tractuosa strain DSM 4126
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