STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADR23091.1Nicotinamidase; COGs: COG1335 Amidase related to nicotinamidase; InterPro IPR000868; KEGG: lpa:lpa_00470 bifunctional pyrazinamidase/nicotinamidase; PFAM: isochorismatase hydrolase; PRIAM: Nicotinamidase; SPTR: Bifunctional pyrazinamidase/nicotinamidase; PFAM: Isochorismatase family. (201 aa)    
Predicted Functional Partners:
ADR23090.1
Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family.
 
 0.998
ADR23087.1
Inosine guanosine and xanthosine phosphorylase family; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
    
 0.932
cobB
Silent information regulator protein Sir2; COGs: COG0846 NAD-dependent protein deacetylase SIR2 family; InterPro IPR003000; KEGG: sli:Slin_2032 silent information regulator protein Sir2; PFAM: Silent information regulator protein Sir2; SPTR: Silent information regulator protein Sir2; PFAM: Sir2 family; Belongs to the sirtuin family. Class III subfamily.
  
 0.923
ADR22664.1
COGs: COG1488 Nicotinic acid phosphoribosyltransferase; InterPro IPR016471: IPR015977; KEGG: cpi:Cpin_0607 putative nicotinate phosphoribosyltransferase; PFAM: Nicotinate phosphoribosyltransferase-like; PRIAM: Nicotinamide phosphoribosyltransferase; SPTR: Nicotinamide phosphoribosyltransferase; PFAM: Nicotinate phosphoribosyltransferase (NAPRTase) family; Belongs to the NAPRTase family.
  
 
 0.918
ADR23089.1
Appr-1-p processing domain protein; COGs: COG2110 phosphatase homologous to the C-terminal domain of histone macroH2A1; InterPro IPR002589; KEGG: ilo:IL0105 phosphatase; PFAM: Appr-1-p processing domain protein; SMART: Appr-1-p processing domain protein; SPTR: Predicted phosphatase; PFAM: Macro domain.
       0.730
ADR21615.1
COGs: COG1257 Hydroxymethylglutaryl-CoA reductase; InterPro IPR002202; KEGG: vfm:VFMJ11_A0972 hydroxymethylglutaryl-coenzyme A reductase; PFAM: hydroxymethylglutaryl-coenzyme A reductase; PRIAM: Hydroxymethylglutaryl-CoA reductase (NADPH); SPTR: Hydroxymethylglutaryl-CoA reductase (NADPH); PFAM: Hydroxymethylglutaryl-coenzyme A reductase; TIGRFAM: 3-hydroxy-3-methylglutaryl Coenzyme A reductase, hydroxymethylglutaryl-CoA reductase (NADP).
 
      0.597
ADR22498.1
COGs: COG0380 Trehalose-6-phosphate synthase; InterPro IPR003337: IPR006379: IPR001830; KEGG: cpi:Cpin_4022 trehalose-phosphatase; PFAM: glycosyl transferase family 20; trehalose-phosphatase; SPTR: Trehalose-6-phosphate synthase-phosphatase; TIGRFAM: trehalose-phosphatase; HAD-superfamily hydrolase, subfamily IIB; PFAM: Trehalose-phosphatase; Glycosyltransferase family 20; TIGRFAM: trehalose-phosphatase; alpha,alpha-trehalose-phosphate synthase [UDP-forming]; HAD-superfamily hydrolase, subfamily IIB.
  
    0.547
nnrD
Carbohydrate kinase, YjeF related protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow t [...]
  
    0.536
ADR23088.1
Phosphate-selective porin O and P; InterPro IPR010870: IPR010917; KEGG: fjo:Fjoh_0542 phosphate-selective porin O and P; PFAM: phosphate-selective porin O and P; SPTR: Putative uncharacterized protein; PFAM: Phosphate-selective porin O and P.
       0.508
nadE
NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
 
 
 0.477
Your Current Organism:
Marivirga tractuosa
NCBI taxonomy Id: 643867
Other names: Flexibacter tractuosus DSM 4126, Flexibacter tractuosus IFO 15989, M. tractuosa DSM 4126, Marivirga tractuosa DSM 4126, Marivirga tractuosa IFO 15989, Marivirga tractuosa str. DSM 4126, Marivirga tractuosa strain DSM 4126
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.