STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
kbl2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. (395 aa)    
Predicted Functional Partners:
gcvP
Glycine dehydrogenase (decarboxylating) beta subunit; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
  
 
 0.935
ADR21569.1
Glycine C-acetyltransferase; COGs: COG0156 7-keto-8-aminopelargonate synthetase; InterPro IPR004839: IPR001917; KEGG: chu:CHU_1310 2-amino-3-ketobutyrate CoA ligase (glycine acetyltransferase); PFAM: aminotransferase class I and II; PRIAM: Glycine C-acetyltransferase; SPTR: 8-amino-7-oxononanoate synthase; PFAM: Aminotransferase class I and II.
  
  
 
0.919
ADR23063.1
2-amino-3-ketobutyrate coenzyme A ligase; COGs: COG0156 7-keto-8-aminopelargonate synthetase; InterPro IPR004839: IPR001917; KEGG: csc:Csac_1225 glycine C-acetyltransferase; PFAM: aminotransferase class I and II; PRIAM: Glycine C-acetyltransferase; SPTR: 2-amino-3-ketobutyrate coenzyme A ligase; PFAM: Aminotransferase class I and II; TIGRFAM: 8-amino-7-oxononanoate synthase.
  
  
 
0.913
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.913
ADR22785.1
COGs: COG2008 Threonine aldolase; InterPro IPR001597; KEGG: dfe:Dfer_4745 threonine aldolase; PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase; PRIAM: Threonine aldolase; SPTR: Threonine aldolase; PFAM: Beta-eliminating lyase.
   
 
 0.909
ADR20029.1
FAD dependent oxidoreductase; COGs: COG0665 Glycine/D-amino acid oxidase (deaminating); InterPro IPR006076; KEGG: ddi:DDB_G0268008 hypothetical protein; PFAM: FAD dependent oxidoreductase; SPTR: FAD dependent oxidoreductase; PFAM: FAD dependent oxidoreductase.
  
 
 0.907
ADR21009.1
COGs: COG0161 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; InterPro IPR005814: IPR005815; KEGG: phe:Phep_2566 adenosylmethionine-8-amino-7-oxononanoate aminotransferase; PFAM: aminotransferase class-III; SPTR: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; TIGRFAM: adenosylmethionine-8-amino-7-oxononanoate aminotransferase; PFAM: Aminotransferase class-III; TIGRFAM: adenosylmethionine-8-amino-7-oxononanoate transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
 
  
 0.639
bioD
Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring.
  
  
 0.625
bioB
Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family.
 
  
 0.621
ADR22932.1
NAD-dependent epimerase/dehydratase; COGs: COG0451 Nucleoside-diphosphate-sugar epimerase; InterPro IPR001509; KEGG: cpi:Cpin_2021 NAD-dependent epimerase/dehydratase; PFAM: NAD-dependent epimerase/dehydratase; SPTR: Putative oxidoreductase protein; PFAM: NAD dependent epimerase/dehydratase family.
 
  
 0.509
Your Current Organism:
Marivirga tractuosa
NCBI taxonomy Id: 643867
Other names: Flexibacter tractuosus DSM 4126, Flexibacter tractuosus IFO 15989, M. tractuosa DSM 4126, Marivirga tractuosa DSM 4126, Marivirga tractuosa IFO 15989, Marivirga tractuosa str. DSM 4126, Marivirga tractuosa strain DSM 4126
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