STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
C4QZP0_KOMPGFructose-2,6-bisphosphatase, required for glucose metabolism. (449 aa)    
Predicted Functional Partners:
C4R7C5_KOMPG
Similar to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase enzymes.
  
0.982
C4R5T8_KOMPG
Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway; Belongs to the FBPase class 1 family.
   
 
 0.949
PFK2
ATP-dependent 6-phosphofructokinase subunit beta; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
   
 0.938
PFK1
ATP-dependent 6-phosphofructokinase subunit alpha; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis (By similarity). Involved in the modulation of glucose- induced microautophagy of peroxisomes independent of its ability to metabolize glucose intermediates.
   
 0.938
C4R8F9_KOMPG
Phosphotransferase.
   
 0.911
C4QYH5_KOMPG
Phosphotransferase.
   
 0.908
C4QYU3_KOMPG
Phosphotransferase.
   
 0.908
C4R4M0_KOMPG
Phosphotransferase.
   
 0.908
C4R6J6_KOMPG
Mannose-6-phosphate isomerase.
   
 
 0.904
NCS6
Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.
      0.891
Your Current Organism:
Komagataella phaffii
NCBI taxonomy Id: 644223
Other names: K. phaffii GS115, Komagataella phaffii GS115
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