STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
C4QZX5_KOMPG3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (448 aa)    
Predicted Functional Partners:
C4R2G2_KOMPG
3-hydroxy-3-methylglutaryl coenzyme A reductase.
  
 
 0.999
C4QY22_KOMPG
Acetyl-CoA C-acetyltransferase (Acetoacetyl-CoA thiolase), cytosolic enzyme; Belongs to the thiolase-like superfamily. Thiolase family.
  
 0.997
C4R2C2_KOMPG
3-ketoacyl-CoA thiolase with broad chain length specificity; Belongs to the thiolase-like superfamily. Thiolase family.
  
 0.994
C4R6L8_KOMPG
Fungal_trans domain-containing protein.
  
 0.950
C4R632_KOMPG
Lanosterol 14-alpha-demethylase, catalyzes the C-14 demethylation of lanosterol; Belongs to the cytochrome P450 family.
  
 
 0.929
C4R3L8_KOMPG
Squalene epoxidase, catalyzes the epoxidation of squalene to 2,3-oxidosqualene.
   
  
 0.926
C4R3E6_KOMPG
Methylsterol monooxygenase; Belongs to the sterol desaturase family.
   
  
 0.903
C4R470_KOMPG
Farnesyl-diphosphate farnesyl transferase (Squalene synthase).
   
 
 0.899
C4R5P6_KOMPG
Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
     
 0.860
C4QYF6_KOMPG
Isopentenyl diphosphate:dimethylallyl diphosphate isomerase (IPP isomerase).
  
  
 0.859
Your Current Organism:
Komagataella phaffii
NCBI taxonomy Id: 644223
Other names: K. phaffii GS115, Komagataella phaffii GS115
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