STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
C4R321_KOMPGCell-cycle checkpoint serine-threonine kinase. (504 aa)    
Predicted Functional Partners:
C4R6G9_KOMPG
Serine/threonine-protein kinase RAD53; Controls S-phase checkpoint as well as G1 and G2 DNA damage checkpoints. Phosphorylates proteins on serine, threonine, and tyrosine. Prevents entry into anaphase and mitotic exit after DNA damage via regulation of the Polo kinase CDC5.
  
 
0.976
C4R2P9_KOMPG
Major transcriptional repressor of DNA-damage-regulated genes.
   
 0.949
C4R4F6_KOMPG
BRCT domain-containing protein.
    
 0.927
C4QVC9_KOMPG
Protein kinase primarily involved in telomere length regulation; Belongs to the PI3/PI4-kinase family.
    
 0.925
C4R1P2_KOMPG
General transcriptional co-repressor, acts together with Tup1p.
    
 0.910
C4R677_KOMPG
General repressor of transcription, forms complex with Cyc8p.
 
  
  0.903
C4QWM0_KOMPG
Protein tyrosine phosphatase involved in cell cycle control.
   
 0.892
C4R286_KOMPG
Genome integrity checkpoint protein and PI kinase superfamily member; Belongs to the PI3/PI4-kinase family.
    
 
 0.877
C4R8C0_KOMPG
Serine/threonine kinase and DNA damage checkpoint effector.
  
 
0.861
C4R534_KOMPG
Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity.
  
 
0.809
Your Current Organism:
Komagataella phaffii
NCBI taxonomy Id: 644223
Other names: K. phaffii GS115, Komagataella phaffii GS115
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.