STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
C4R3E5_KOMPGThiamine pyrophosphokinase; Belongs to the thiamine pyrophosphokinase family. (320 aa)    
Predicted Functional Partners:
C4QZN1_KOMPG
One of three repressible acid phosphatases, a glycoprotein that is transported to the cell surface; Belongs to the histidine acid phosphatase family.
     
 0.925
C4QXJ6_KOMPG
Protein with similarity to hydroxymethylpyrimidine phosphate kinases.
    
 0.924
C4R5Q7_KOMPG
Multifunctional protein with both hydroxymethylpyrimidine kinase and thiaminase activities.
    
 0.924
ADK2
GTP:AMP phosphotransferase, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.
     
 0.907
ADK1
Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.
     
 0.907
C4QXK8_KOMPG
Protein phosphotyrosine phosphatase.
    
  0.900
C4R2X1_KOMPG
Alkaline phosphatase.
     
  0.900
C4R4V8_KOMPG
cAMP-dependent protein kinase regulatory subunit.
      
 0.555
THI4
Thiamine thiazole synthase; Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5- (2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron- dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance; Belongs to the T [...]
     
 0.554
C4QZX3_KOMPG
Protein required for respiratory growth and stability of the mitochondrial genome.
    
 0.442
Your Current Organism:
Komagataella phaffii
NCBI taxonomy Id: 644223
Other names: K. phaffii GS115, Komagataella phaffii GS115
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