node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C4QW64_KOMPG | THI4 | C4QW64 | C4R560 | Uncharacterized protein. | Thiamine thiazole synthase; Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5- (2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron- dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance; Belongs to the T [...] | 0.568 |
C4QW68_KOMPG | THI4 | C4QW68 | C4R560 | Uncharacterized protein. | Thiamine thiazole synthase; Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5- (2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron- dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance; Belongs to the T [...] | 0.568 |
C4QXJ6_KOMPG | C4R3E5_KOMPG | C4QXJ6 | C4R3E5 | Protein with similarity to hydroxymethylpyrimidine phosphate kinases. | Thiamine pyrophosphokinase; Belongs to the thiamine pyrophosphokinase family. | 0.924 |
C4QXJ6_KOMPG | C4R5Q7_KOMPG | C4QXJ6 | C4R5Q7 | Protein with similarity to hydroxymethylpyrimidine phosphate kinases. | Multifunctional protein with both hydroxymethylpyrimidine kinase and thiaminase activities. | 0.905 |
C4QXJ6_KOMPG | C4R5Q8_KOMPG | C4QXJ6 | C4R5Q8 | Protein with similarity to hydroxymethylpyrimidine phosphate kinases. | Bifunctional enzyme. | 0.991 |
C4QXJ6_KOMPG | C4R6R6_KOMPG | C4QXJ6 | C4R6R6 | Protein with similarity to hydroxymethylpyrimidine phosphate kinases. | Protein involved in synthesis of the thiamine hydroxymethylpyrimidine (HMP). | 0.921 |
C4QXJ6_KOMPG | THI4 | C4QXJ6 | C4R560 | Protein with similarity to hydroxymethylpyrimidine phosphate kinases. | Thiamine thiazole synthase; Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5- (2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron- dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance; Belongs to the T [...] | 0.594 |
C4QY70_KOMPG | THI4 | C4QY70 | C4R560 | Prefoldin subunit 3; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins; Belongs to the prefoldin subunit alpha family. | Thiamine thiazole synthase; Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5- (2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron- dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance; Belongs to the T [...] | 0.758 |
C4QYI8_KOMPG | C4R3J3_KOMPG | C4QYI8 | C4R3J3 | Malate synthase. | Solute carrier family 25 (peroxisomal adenine nucleotide transporter), member 17; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.688 |
C4QYI8_KOMPG | THI4 | C4QYI8 | C4R560 | Malate synthase. | Thiamine thiazole synthase; Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5- (2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron- dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance; Belongs to the T [...] | 0.633 |
C4R3E5_KOMPG | C4QXJ6_KOMPG | C4R3E5 | C4QXJ6 | Thiamine pyrophosphokinase; Belongs to the thiamine pyrophosphokinase family. | Protein with similarity to hydroxymethylpyrimidine phosphate kinases. | 0.924 |
C4R3E5_KOMPG | C4R5Q7_KOMPG | C4R3E5 | C4R5Q7 | Thiamine pyrophosphokinase; Belongs to the thiamine pyrophosphokinase family. | Multifunctional protein with both hydroxymethylpyrimidine kinase and thiaminase activities. | 0.924 |
C4R3E5_KOMPG | THI4 | C4R3E5 | C4R560 | Thiamine pyrophosphokinase; Belongs to the thiamine pyrophosphokinase family. | Thiamine thiazole synthase; Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5- (2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron- dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance; Belongs to the T [...] | 0.554 |
C4R3J3_KOMPG | C4QYI8_KOMPG | C4R3J3 | C4QYI8 | Solute carrier family 25 (peroxisomal adenine nucleotide transporter), member 17; Belongs to the mitochondrial carrier (TC 2.A.29) family. | Malate synthase. | 0.688 |
C4R3J3_KOMPG | THI4 | C4R3J3 | C4R560 | Solute carrier family 25 (peroxisomal adenine nucleotide transporter), member 17; Belongs to the mitochondrial carrier (TC 2.A.29) family. | Thiamine thiazole synthase; Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5- (2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron- dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance; Belongs to the T [...] | 0.607 |
C4R5Q7_KOMPG | C4QXJ6_KOMPG | C4R5Q7 | C4QXJ6 | Multifunctional protein with both hydroxymethylpyrimidine kinase and thiaminase activities. | Protein with similarity to hydroxymethylpyrimidine phosphate kinases. | 0.905 |
C4R5Q7_KOMPG | C4R3E5_KOMPG | C4R5Q7 | C4R3E5 | Multifunctional protein with both hydroxymethylpyrimidine kinase and thiaminase activities. | Thiamine pyrophosphokinase; Belongs to the thiamine pyrophosphokinase family. | 0.924 |
C4R5Q7_KOMPG | C4R5Q8_KOMPG | C4R5Q7 | C4R5Q8 | Multifunctional protein with both hydroxymethylpyrimidine kinase and thiaminase activities. | Bifunctional enzyme. | 0.989 |
C4R5Q7_KOMPG | C4R6R6_KOMPG | C4R5Q7 | C4R6R6 | Multifunctional protein with both hydroxymethylpyrimidine kinase and thiaminase activities. | Protein involved in synthesis of the thiamine hydroxymethylpyrimidine (HMP). | 0.921 |
C4R5Q7_KOMPG | THI4 | C4R5Q7 | C4R560 | Multifunctional protein with both hydroxymethylpyrimidine kinase and thiaminase activities. | Thiamine thiazole synthase; Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5- (2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron- dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance; Belongs to the T [...] | 0.594 |