STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
C4R5L5_KOMPGDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (563 aa)    
Predicted Functional Partners:
FEN1
Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]
   
 0.948
C4R5E5_KOMPG
DNA ligase.
 
 0.885
C4R6J3_KOMPG
DNA ligase.
  
 0.881
C4QV37_KOMPG
Class II abasic (AP) endonuclease involved in repair of DNA damage.
    
 0.873
C4QWZ0_KOMPG
DNA 3'-phosphatase that functions in repair of endogenous damage of double-stranded DNA.
    
 0.845
C4R481_KOMPG
Subunit of the telomeric Ku complex (Yku70p-Yku80p).
    
 0.836
C4R8T8_KOMPG
Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance.
     
 0.802
C4R462_KOMPG
Required for a post-incision step in the repair of DNA single and double-strand breaks.
    
 0.755
C4QZB7_KOMPG
XPGI domain-containing protein.
   
 0.703
C4R890_KOMPG
Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair.
   
 0.703
Your Current Organism:
Komagataella phaffii
NCBI taxonomy Id: 644223
Other names: K. phaffii GS115, Komagataella phaffii GS115
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.