STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
C4R749_KOMPGC-8 sterol isomerase. (205 aa)    
Predicted Functional Partners:
C4R4C9_KOMPG
Sterol 24-C-methyltransferase; Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol.
   
 0.998
C4QY87_KOMPG
C-5 sterol desaturase, catalyzes the introduction of a C-5(6) double bond into episterol; Belongs to the sterol desaturase family.
   
 0.987
C4R3E6_KOMPG
Methylsterol monooxygenase; Belongs to the sterol desaturase family.
   
 0.986
C4QX15_KOMPG
C-14 sterol reductase, acts in ergosterol biosynthesis.
   
 
 0.985
C4QYY9_KOMPG
C-3 sterol dehydrogenase.
   
 
 0.982
C4R3L8_KOMPG
Squalene epoxidase, catalyzes the epoxidation of squalene to 2,3-oxidosqualene.
   
 
 0.982
C4R632_KOMPG
Lanosterol 14-alpha-demethylase, catalyzes the C-14 demethylation of lanosterol; Belongs to the cytochrome P450 family.
   
 
 0.982
C4R4V9_KOMPG
Endoplasmic reticulum membrane protein.
   
 
 0.979
NCS6
Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.
 
      0.820
C4R6R4_KOMPG
C-24(28) sterol reductase, catalyzes the final step in ergosterol biosynthesis.
   
 
 0.807
Your Current Organism:
Komagataella phaffii
NCBI taxonomy Id: 644223
Other names: K. phaffii GS115, Komagataella phaffii GS115
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