STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
PURA_KOMPGAdenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity). Belongs to the adenylosuccinate synthetase family. (428 aa)    
Predicted Functional Partners:
C4R253_KOMPG
Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
  
 0.999
C4R1D1_KOMPG
Enzyme of 'de novo' purine biosynthesis.
  
 0.994
C4QXL7_KOMPG
Histidine biosynthesis trifunctional protein.
  
  
 0.979
C4QZ48_KOMPG
A_deaminase domain-containing protein; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
  
 
 0.962
HAM1
Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
   
 0.962
C4R3W1_KOMPG
Arginosuccinate synthetase.
  
 
 0.960
C4R2Q9_KOMPG
Bifunctional carbamoylphosphate synthetase (CPSase)-aspartate transcarbamylase (ATCase).
  
 
 0.946
C4R5V8_KOMPG
Dimeric hypoxanthine-guanine phosphoribosyltransferase.
    
 0.946
C4R588_KOMPG
Asparagine synthetase, isozyme of Asn1p.
  
 
 0.936
C4QWE4_KOMPG
Aspartate aminotransferase.
  
 0.933
Your Current Organism:
Komagataella phaffii
NCBI taxonomy Id: 644223
Other names: K. phaffii GS115, Komagataella phaffii GS115
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