node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADC69136.1 | ADC69137.1 | MFS40622_0442 | MFS40622_0443 | TIGRFAM: Sua5/YciO/YrdC/YwlC family protein; PFAM: SUA5/yciO/yrdC domain; KEGG: mja:MJ0062 hypothetical protein. | PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: mja:MJ0061 ferredoxin. | 0.788 |
ADC69136.1 | ADC69138.1 | MFS40622_0442 | MFS40622_0444 | TIGRFAM: Sua5/YciO/YrdC/YwlC family protein; PFAM: SUA5/yciO/yrdC domain; KEGG: mja:MJ0062 hypothetical protein. | Methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | 0.875 |
ADC69137.1 | ADC69136.1 | MFS40622_0443 | MFS40622_0442 | PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: mja:MJ0061 ferredoxin. | TIGRFAM: Sua5/YciO/YrdC/YwlC family protein; PFAM: SUA5/yciO/yrdC domain; KEGG: mja:MJ0062 hypothetical protein. | 0.788 |
ADC69137.1 | ADC69138.1 | MFS40622_0443 | MFS40622_0444 | PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: mja:MJ0061 ferredoxin. | Methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | 0.787 |
ADC69138.1 | ADC69136.1 | MFS40622_0444 | MFS40622_0442 | Methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | TIGRFAM: Sua5/YciO/YrdC/YwlC family protein; PFAM: SUA5/yciO/yrdC domain; KEGG: mja:MJ0062 hypothetical protein. | 0.875 |
ADC69138.1 | ADC69137.1 | MFS40622_0444 | MFS40622_0443 | Methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: mja:MJ0061 ferredoxin. | 0.787 |
ADC69138.1 | ADC69551.1 | MFS40622_0444 | MFS40622_0869 | Methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | PFAM: class II aldolase/adducin family protein; KEGG: mja:MJ1418 fuculose-1-phosphate aldolase (FucA). | 0.687 |
ADC69138.1 | ADC69608.1 | MFS40622_0444 | MFS40622_0927 | Methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | PFAM: CBS domain containing protein; peptidase M50; SMART: CBS domain containing protein; KEGG: mja:MJ0392 hypothetical protein; Belongs to the peptidase M50B family. | 0.616 |
ADC69138.1 | ADC70346.1 | MFS40622_0444 | MFS40622_1675 | Methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | PFAM: PfkB domain protein; KEGG: mja:MJ0406 ribokinase (RbsK); Belongs to the carbohydrate kinase PfkB family. | 0.685 |
ADC69138.1 | ADC70393.1 | MFS40622_0444 | MFS40622_1722 | Methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | Translation initiation factor, aIF-2BI family; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily. | 0.992 |
ADC69138.1 | dadD | MFS40622_0444 | MFS40622_0746 | Methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | Amidohydrolase; Catalyzes the deamination of three SAM-derived enzymatic products, namely 5'-deoxyadenosine, S-adenosyl-L-homocysteine, and 5'- methylthioadenosine, to produce the inosine analogs. Can also deaminate adenosine. The preferred substrate for this enzyme is 5'- deoxyadenosine, but all these substrates are efficiently deaminated. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. May also be involved in the recycling of 5'- deoxyadenosine, whereupon the 5'-deoxyribose m [...] | 0.996 |
ADC69138.1 | hpt | MFS40622_0444 | MFS40622_0597 | Methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | Phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. | 0.627 |
ADC69138.1 | pgi | MFS40622_0444 | MFS40622_0159 | Methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | PFAM: phosphoglucose isomerase (PGI); KEGG: mja:MJ1605 glucose-6-phosphate isomerase; Belongs to the GPI family. | 0.617 |
ADC69138.1 | speE | MFS40622_0444 | MFS40622_1086 | Methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | Spermidine synthase; Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine; Belongs to the spermidine/spermine synthase family. | 0.943 |
ADC69551.1 | ADC69138.1 | MFS40622_0869 | MFS40622_0444 | PFAM: class II aldolase/adducin family protein; KEGG: mja:MJ1418 fuculose-1-phosphate aldolase (FucA). | Methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | 0.687 |
ADC69551.1 | ADC70393.1 | MFS40622_0869 | MFS40622_1722 | PFAM: class II aldolase/adducin family protein; KEGG: mja:MJ1418 fuculose-1-phosphate aldolase (FucA). | Translation initiation factor, aIF-2BI family; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily. | 0.704 |
ADC69551.1 | dadD | MFS40622_0869 | MFS40622_0746 | PFAM: class II aldolase/adducin family protein; KEGG: mja:MJ1418 fuculose-1-phosphate aldolase (FucA). | Amidohydrolase; Catalyzes the deamination of three SAM-derived enzymatic products, namely 5'-deoxyadenosine, S-adenosyl-L-homocysteine, and 5'- methylthioadenosine, to produce the inosine analogs. Can also deaminate adenosine. The preferred substrate for this enzyme is 5'- deoxyadenosine, but all these substrates are efficiently deaminated. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. May also be involved in the recycling of 5'- deoxyadenosine, whereupon the 5'-deoxyribose m [...] | 0.637 |
ADC69551.1 | hpt | MFS40622_0869 | MFS40622_0597 | PFAM: class II aldolase/adducin family protein; KEGG: mja:MJ1418 fuculose-1-phosphate aldolase (FucA). | Phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. | 0.504 |
ADC69551.1 | pgi | MFS40622_0869 | MFS40622_0159 | PFAM: class II aldolase/adducin family protein; KEGG: mja:MJ1418 fuculose-1-phosphate aldolase (FucA). | PFAM: phosphoglucose isomerase (PGI); KEGG: mja:MJ1605 glucose-6-phosphate isomerase; Belongs to the GPI family. | 0.429 |
ADC69551.1 | speE | MFS40622_0869 | MFS40622_1086 | PFAM: class II aldolase/adducin family protein; KEGG: mja:MJ1418 fuculose-1-phosphate aldolase (FucA). | Spermidine synthase; Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine; Belongs to the spermidine/spermine synthase family. | 0.418 |