STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rgyReverse gyrase; Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication; In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family. (1119 aa)    
Predicted Functional Partners:
ADC69059.1
PFAM: stem cell self-renewal protein Piwi domain protein; KEGG: ton:TON_1506 hypothetical protein.
      
 0.853
ADC69415.1
Protein of unknown function DUF265; Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency; Belongs to the THEP1 NTPase family.
  
   
 0.715
fbp
Protein of unknown function DUF100; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
  
   
 0.656
ADC69319.1
Transcriptional regulator, XRE family; PFAM: Replication factor C; helix-turn-helix domain protein; SMART: Hedgehog/intein hint domain protein; helix-turn-helix domain protein; KEGG: mja:MJ1422 replication factor C small subunit.
  
   
 0.637
ADC69560.1
PFAM: Circadian clock protein KaiC central region; KaiA binding; KEGG: mja:MJ1359 hypothetical protein; Belongs to the UPF0273 family.
 
     0.575
dnaG
TOPRIM domain protein; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.
      
 0.573
ADC70361.1
PFAM: THUMP domain protein; KEGG: mja:MJ0421 hypothetical protein.
  
   
 0.547
taw3
Protein of unknown function DUF207; S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72; Belongs to the TYW3 family.
 
     0.452
ADC69212.1
PFAM: Carboxymuconolactone decarboxylase; KEGG: mja:MJ1511 hypothetical protein.
       0.449
ADC69334.1
KEGG: mja:MJ1629 hypothetical protein; Belongs to the UPF0282 family.
  
     0.420
Your Current Organism:
Methanocaldococcus sp. FS40622
NCBI taxonomy Id: 644281
Other names: M. sp. FS406-22, Methanocaldococcus sp. FS406-22
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