STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hisIPhosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (132 aa)    
Predicted Functional Partners:
hisA
KEGG: mja:MJ1532 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (hisA1); TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein.
 
 0.999
hisF
Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
  
 0.998
hisE
TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: mja:MJ0302 phosphoribosyl-ATP pyrophosphatase.
 
 
 0.997
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
 
  
 0.992
hisB
PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: mja:MJ0698 imidazoleglycerol-phosphate dehydratase.
 
  
 0.990
hisG
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
 
  
 0.989
hisH
Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
 
  
 0.989
hisC
TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; KEGG: mfe:Mefer_0844 histidinol-phosphate aminotransferase.
 
  
 0.982
ADC70146.1
TIGRFAM: hisA/hisF family protein; PFAM: histidine biosynthesis protein; KEGG: mja:MJ0703 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (hisA2); Belongs to the HisA/HisF family.
  
  
  0.913
ADC68760.1
KEGG: mja:MJ1594 phosphoserine phosphatase (SerB); TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: Haloacid dehalogenase domain protein hydrolase.
  
  
 0.843
Your Current Organism:
Methanocaldococcus sp. FS40622
NCBI taxonomy Id: 644281
Other names: M. sp. FS406-22, Methanocaldococcus sp. FS406-22
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