STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADC69928.1PFAM: CobN/magnesium chelatase; KEGG: mja:MJ0908 cobalamin biosynthesis protein (CobN). (1228 aa)    
Predicted Functional Partners:
cbiA
Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP- dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source.
 
 
 0.950
ADC69966.1
PFAM: CobN/magnesium chelatase; KEGG: mtp:Mthe_0835 cobaltochelatase.
  
  
 
0.912
ADC69300.1
PFAM: CobN/magnesium chelatase; KEGG: mja:MJ1441 cobaltochelatase subunit CobN.
  
  
 
0.909
ADC69926.1
KEGG: mja:MJ0911 magnesium-chelatase subunit (ChlI); PFAM: ATPase associated with various cellular activities AAA_5; SMART: AAA ATPase.
 
  
 0.803
ADC69927.1
KEGG: mfe:Mefer_1198 magnesium chelatase; PFAM: von Willebrand factor type A; SMART: von Willebrand factor type A.
 
  
 0.749
ADC69151.1
PFAM: Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase; KEGG: mja:MJ1598 hypothetical protein; Belongs to the UPF0284 family.
     
 0.727
cobS
Cobalamin 5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family.
     
 0.682
cbiX
Cobalamin (vitamin B12) biosynthesis CbiX protein; Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni- sirohydrochlorin.
 
   
 0.659
ADC69259.1
PFAM: Cobyrinic acid ac-diamide synthase; CobB/CobQ domain protein glutamine amidotransferase; KEGG: mja:MJ0138 cobyrinic acid a,c-diamide synthase.
  
 
 0.645
ADC69929.1
PFAM: Radical SAM domain protein; KEGG: mja:MJ0907 chondro-6-sulfatase regulatory protein isolog.
 
     0.617
Your Current Organism:
Methanocaldococcus sp. FS40622
NCBI taxonomy Id: 644281
Other names: M. sp. FS406-22, Methanocaldococcus sp. FS406-22
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