STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADC70280.1PFAM: Mandelate racemase/muconate lactonizing protein; KEGG: fnu:FN1586 O-succinylbenzoate-CoA synthase. (355 aa)    
Predicted Functional Partners:
ADC70279.1
PFAM: protein of unknown function DUF1611; KEGG: mka:MK0569 hypothetical protein.
 
     0.901
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
       0.441
ADC69201.1
PFAM: peptidase dimerisation domain protein; peptidase M20; KEGG: mja:MJ1497 acetylornithine deacetylase (ArgE).
 
   
 0.432
ADC69286.1
5-carboxymethyl-2-hydroxymuconate Delta-isomerase; PFAM: fumarylacetoacetate (FAA) hydrolase; KEGG: mja:MJ1656 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HpcE).
  
  
 0.403
dapA
Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
     
 0.402
Your Current Organism:
Methanocaldococcus sp. FS40622
NCBI taxonomy Id: 644281
Other names: M. sp. FS406-22, Methanocaldococcus sp. FS406-22
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