Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
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Deba_0205Phosphomethylpyrimidine kinase; COGs: COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase; InterPro IPR013749:IPR004399; KEGG: pla:Plav_2132 phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1; SPTR: A7HV13 Phosphomethylpyrimidine kinase; TIGRFAM: phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase; TIGRFAM: phosphomethylpyrimidine kinase. (304 aa)    
Predicted Functional Partners:
thiE
Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
 
 0.999
thiC
Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
 
 
 0.996
thiM
Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family.
  
 0.995
Deba_2032
COGs: COG0422 Thiamine biosynthesis protein ThiC; InterPro IPR002817; KEGG: geo:Geob_0543 thiamine biosynthesis protein ThiC; PFAM: thiamine biosynthesis protein ThiC; SPTR: B9LZU6 Thiamine biosynthesis protein ThiC; TIGRFAM: thiamine biosynthesis protein ThiC; PFAM: ThiC family; TIGRFAM: thiamine biosynthesis protein ThiC.
 
 
 0.923
birA
biotin/acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.
     
 0.904
Deba_3171
UBA/THIF-type NAD/FAD binding protein; COGs: COG1179 Dinucleotide-utilizing protein involved in molybdopterin and thiamine biosynthesis family 1; InterPro IPR009036:IPR000594:IPR016040; KEGG: reh:H16_A1870 ThiF/MoeB/HesA family protein; PFAM: UBA/THIF-type NAD/FAD binding protein; SPTR: A1HS23 UBA/THIF-type NAD/FAD binding protein; PFAM: ThiF family.
  
  
 0.817
Deba_0207
Mannosyl-3-phosphoglycerate phosphatase family; COGs: COG3769 hydrolase (HAD superfamily); InterPro IPR013200:IPR006381:IPR006379; KEGG: rmr:Rmar_0501 mannosyl-3-phosphoglycerate phosphatase; PFAM: Haloacid dehalogenase domain protein hydrolase type 3; PRIAM: Mannosyl-3-phosphoglycerate phosphatase; SPTR: D0MEV3 Mannosyl-3-phosphoglycerate phosphatase; TIGRFAM: mannosyl-3-phosphoglycerate phosphatase family; HAD-superfamily hydrolase, subfamily IIB; PFAM: haloacid dehalogenase-like hydrolase; TIGRFAM: mannosyl-3-phosphoglycerate phosphatase family; HAD-superfamily hydrolase, subfamily [...]
       0.782
thi4
Thiazole biosynthesis enzyme; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
  
  
 0.744
truA
tRNA pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
  
    0.674
Deba_2382
Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.
   
  
 0.517
Your Current Organism:
Desulfarculus baarsii
NCBI taxonomy Id: 644282
Other names: D. baarsii DSM 2075, Desulfarculus baarsii 2st 14, Desulfarculus baarsii DSM 2075, Desulfarculus baarsii str. DSM 2075, Desulfarculus baarsii strain DSM 2075
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