Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Deba_0231Metal dependent phosphohydrolase; COGs: COG3481 HD-superfamily hydrolase; InterPro IPR004365:IPR006674:IPR003607:IPR006675; KEGG: gsu:GSU1122 HD domain-containing protein; PFAM: metal-dependent phosphohydrolase HD sub domain; nucleic acid binding OB-fold tRNA/helicase-type; SMART: metal-dependent phosphohydrolase HD region; SPTR: C6MSS8 Metal dependent phosphohydrolase; TIGRFAM: metal dependent phophohydrolase; PFAM: HD domain; OB-fold nucleic acid binding domain; TIGRFAM: uncharacterized domain HDIG. (345 aa)    
Predicted Functional Partners:
purL
Phosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...]
  
    0.955
tmk
Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.
     
 0.837
Deba_0230
COGs: COG0047 Phosphoribosylformylglycinamidine (FGAM) synthase glutamine amidotransferase domain; InterPro IPR010075; KEGG: dol:Dole_0483 phosphoribosylformylglycinamidine synthase; PRIAM: Phosphoribosylformylglycinamidine synthase; SPTR: A8ZTM9 Phosphoribosylformylglycinamidine synthase.
  
    0.803
Deba_0233
COGs: COG2812 DNA polymerase III gamma/tau subunits; KEGG: afw:Anae109_2451 DNA polymerase III, delta prime subunit; SPTR: A7HD56 DNA polymerase III, delta prime subunit; TIGRFAM: DNA polymerase III, delta' subunit.
       0.791
metG
methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
  
    0.759
Deba_0234
PSP1 domain protein; COGs: COG1774 Uncharacterized homolog of PSP1; InterPro IPR007557; KEGG: dal:Dalk_0025 PSP1 domain protein; PFAM: PSP1 domain protein; SPTR: B8FKC0 PSP1 domain protein; PFAM: PSP1 C-terminal conserved region.
  
    0.686
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
    0.547
Deba_0228
Protein of unknown function DUF721; InterPro IPR007922; KEGG: ppd:Ppro_1102 hypothetical protein; PFAM: protein of unknown function DUF721; SPTR: A1AN07 Putative uncharacterized protein; PFAM: Protein of unknown function (DUF721).
       0.491
Deba_1206
Chromosome segregation and condensation protein, ScpB; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves.
   
    0.462
Deba_2382
Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.
       0.459
Your Current Organism:
Desulfarculus baarsii
NCBI taxonomy Id: 644282
Other names: D. baarsii DSM 2075, Desulfarculus baarsii 2st 14, Desulfarculus baarsii DSM 2075, Desulfarculus baarsii str. DSM 2075, Desulfarculus baarsii strain DSM 2075
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