Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
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[Homology]
Score
Deba_0234PSP1 domain protein; COGs: COG1774 Uncharacterized homolog of PSP1; InterPro IPR007557; KEGG: dal:Dalk_0025 PSP1 domain protein; PFAM: PSP1 domain protein; SPTR: B8FKC0 PSP1 domain protein; PFAM: PSP1 C-terminal conserved region. (402 aa)    
Predicted Functional Partners:
metG
methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
       0.861
rny
Metal dependent phosphohydrolase; Endoribonuclease that initiates mRNA decay.
 
  
 0.771
purL
Phosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...]
       0.694
Deba_0231
Metal dependent phosphohydrolase; COGs: COG3481 HD-superfamily hydrolase; InterPro IPR004365:IPR006674:IPR003607:IPR006675; KEGG: gsu:GSU1122 HD domain-containing protein; PFAM: metal-dependent phosphohydrolase HD sub domain; nucleic acid binding OB-fold tRNA/helicase-type; SMART: metal-dependent phosphohydrolase HD region; SPTR: C6MSS8 Metal dependent phosphohydrolase; TIGRFAM: metal dependent phophohydrolase; PFAM: HD domain; OB-fold nucleic acid binding domain; TIGRFAM: uncharacterized domain HDIG.
  
    0.686
tmk
Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.
  
    0.681
Deba_0233
COGs: COG2812 DNA polymerase III gamma/tau subunits; KEGG: afw:Anae109_2451 DNA polymerase III, delta prime subunit; SPTR: A7HD56 DNA polymerase III, delta prime subunit; TIGRFAM: DNA polymerase III, delta' subunit.
  
   0.668
Deba_0230
COGs: COG0047 Phosphoribosylformylglycinamidine (FGAM) synthase glutamine amidotransferase domain; InterPro IPR010075; KEGG: dol:Dole_0483 phosphoribosylformylglycinamidine synthase; PRIAM: Phosphoribosylformylglycinamidine synthase; SPTR: A8ZTM9 Phosphoribosylformylglycinamidine synthase.
       0.607
Deba_2876
Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulfur cluster binding domain protein; COGs: COG0543 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductase; InterProIPR008333:IPR001433:IPR019480:IPR012165:IPR 017927:IPR017938; KEGG: dps:DP3016 dihydroorotate dehydrogenase, electron transfer subunit; PFAM: Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain; Oxidoreductase FAD-binding domain protein; oxidoreductase FAD/NAD(P)-binding domain protein; SPTR: Q1NN17 Oxidoreductase FAD/NAD(P)-binding:Oxidoreductase FAD-bind [...]
 
  
 0.577
fliE
COGs: COG1677 Flagellar hook-basal body protein; InterPro IPR001624; KEGG: gem:GM21_3923 flagellar hook-basal body complex subunit FliE; PFAM: flagellar hook-basal body complex protein FliE; SPTR: C6MM83 Flagellar hook-basal body complex subunit FliE; TIGRFAM: flagellar hook-basal body complex subunit FliE; PFAM: Flagellar hook-basal body complex protein FliE; TIGRFAM: flagellar hook-basal body complex protein FliE.
 
 
   0.567
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
       0.529
Your Current Organism:
Desulfarculus baarsii
NCBI taxonomy Id: 644282
Other names: D. baarsii DSM 2075, Desulfarculus baarsii 2st 14, Desulfarculus baarsii DSM 2075, Desulfarculus baarsii str. DSM 2075, Desulfarculus baarsii strain DSM 2075
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