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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rtcBProtein of unknown function UPF0027; COGs: COG1690 conserved hypothetical protein; InterPro IPR001233; KEGG: pca:Pcar_0019 hypothetical protein; PFAM: protein of unknown function UPF0027; SPTR: Q3A8L0 Putative uncharacterized protein; PFAM: Uncharacterized protein family UPF0027; Belongs to the RtcB family. (480 aa)    
Predicted Functional Partners:
Deba_1622
COGs: COG0430 RNA 3'-terminal phosphate cyclase; InterPro IPR013792:IPR000228:IPR013796; KEGG: pcl:Pcal_2009 RNA 3'-terminal-phosphate cyclase; PFAM: RNA 3'-terminal phosphate cyclase; RNA 3'-terminal phosphate cyclase insert region; PRIAM: RNA-3'-phosphate cyclase; SPTR: A3MXQ7 Probable RNA 3'-terminal phosphate cyclase; PFAM: RNA 3'-terminal phosphate cyclase (RTC), insert domain; RNA 3'-terminal phosphate cyclase; TIGRFAM: RNA 3'-phosphate cyclase.
 
  
 0.899
Deba_0261
COGs: COG0778 Nitroreductase; InterPro IPR001450:IPR000415:IPR017896:IPR017900; KEGG: dol:Dole_1688 nitroreductase; PFAM: nitroreductase; 4Fe-4S ferredoxin iron-sulfur binding domain protein; SPTR: A9A0J2 Nitroreductase; PFAM: Nitroreductase family.
  
  
 0.748
Deba_0905
COGs: COG1503 Peptide chain release factor 1 (eRF1); KEGG: rmr:Rmar_2532 peptide chain release factor 1 (eRF1)-like protein; SPTR: D0MFR9 Peptide chain release factor 1 (ERF1)-like protein.
 
    0.729
gyrA
DNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
     
 0.700
gpsA
NAD-dependent glycerol-3-phosphate dehydrogenase domain protein; COGs: COG0240 Glycerol-3-phosphate dehydrogenase; InterProIPR011128:IPR006109:IPR008927:IPR016040:IPR 006168:IPR013328; KEGG: gem:GM21_0007 glycerol-3-phosphate dehydrogenase (NAD(P)(+)); PFAM: NAD-dependent glycerol-3-phosphate dehydrogenase domain protein; SPTR: C6E7R1 Glycerol-3-phosphate dehydrogenase [NAD(P)+]; PFAM: NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
       0.664
Deba_2577
Helicase domain protein; COGs: COG0553 Superfamily II DNA/RNA helicase SNF2 family; InterPro IPR014001:IPR001650:IPR000330:IPR014021; KEGG: sfu:Sfum_3846 helicase domain-containing protein; PFAM: helicase domain protein; SNF2-related protein; SMART: DEAD-like helicase; helicase domain protein; SPTR: A0LQ13 Helicase domain protein; manually curated; PFAM: Helicase conserved C-terminal domain; SNF2 family N-terminal domain.
   
 0.654
Deba_1142
2'-5' RNA ligase; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family.
 
   
 0.511
Deba_1685
ABC transporter related protein; COGs: COG1116 ABC-type nitrate/sulfonate/bicarbonate transport system ATPase component; InterPro IPR003593:IPR000515:IPR003439:IPR017871; KEGG: dsa:Desal_1875 binding-protein-dependent transport systems inner membrane component; PFAM: ABC transporter related; binding-protein-dependent transport systems inner membrane component; SMART: AAA ATPase; SPTR: C6BUC7 Binding-protein-dependent transport systems inner membrane component; PFAM: ABC transporter; Binding-protein-dependent transport system inner membrane component.
 
     0.498
Deba_1209
Polynucleotide adenylyltransferase region; COGs: COG0617 tRNA nucleotidyltransferase/poly(A) polymerase; InterPro IPR001667:IPR003156:IPR000644:IPR002646; KEGG: sfu:Sfum_0679 polynucleotide adenylyltransferase region; PFAM: Polynucleotide adenylyltransferase region; CBS domain containing protein; phosphoesterase RecJ domain protein; phosphoesterase DHHA1; SMART: CBS domain containing protein; SPTR: A0LG26 Polynucleotide adenylyltransferase region; PFAM: DHH family; DHHA1 domain; CBS domain; Poly A polymerase head domain; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.
     
 0.495
prfB
LigA; Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.
  
  
 0.458
Your Current Organism:
Desulfarculus baarsii
NCBI taxonomy Id: 644282
Other names: D. baarsii DSM 2075, Desulfarculus baarsii 2st 14, Desulfarculus baarsii DSM 2075, Desulfarculus baarsii str. DSM 2075, Desulfarculus baarsii strain DSM 2075
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