close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Deba_0393Beta-lactamase; COGs: COG1237 Metal-dependent hydrolase of the beta-lactamase superfamily II; KEGG: rpd:RPD_2374 beta-lactamase-like; SPTR: Q137Y3 Beta-lactamase-like; PFAM: Metallo-beta-lactamase superfamily. (326 aa)    
Predicted Functional Partners:
Deba_0763
Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
     
 0.911
Deba_1872
2-amino-4-hydroxy-6-hydroxymethyldihydropteridin epyrophosphokinase; COGs: COG0801 7 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; InterPro IPR000550; KEGG: xac:XAC1784 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine; PFAM: 78-dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK; PRIAM:2-amino-4-hydroxy-6-hydroxymethyldihydropteri dinediphosphokinase; SPTR: B7A5Y7 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; TIGRFAM:2-amino-4-hydroxy-6-hydroxymethyldihydropte ridinepyrophosphokinase; PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK); TIGRFA [...]
     
  0.900
Deba_2677
Beta-lactamase domain protein; COGs: COG1237 Metal-dependent hydrolase of the beta-lactamase superfamily II; KEGG: adg:Adeg_1793 beta-lactamase domain protein; SPTR: C9R9A2 Beta-lactamase domain protein; PFAM: Metallo-beta-lactamase superfamily.
     
  0.900
Deba_0394
InterPro IPR011006:IPR001789; KEGG: dal:Dalk_2680 response regulator receiver protein; SMART: response regulator receiver; SPTR: B8FIY1 Response regulator receiver protein; PFAM: Response regulator receiver domain.
       0.490
Deba_0392
COGs: COG4191 Signal transduction histidine kinase regulating C4-dicarboxylate transport system; InterProIPR013656:IPR013767:IPR003661:IPR003594:IPR 001789:IPR011006:IPR009082:IPR000014:IPR001610:IPR004358:I PR005467:IPR000700; KEGG: ppd:Ppro_3150 PAS/PAC sensor hybrid histidine kinase; PFAM: ATP-binding region ATPase domain protein; PAS fold-4 domain protein; PAS fold domain protein; histidine kinase A domain protein; response regulator receiver; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS domain containing protein; PAC repeat-containing pro [...]
       0.482
Deba_2128
Hypothetical protein; KEGG: gur:Gura_3066 cache type 2 domain-containing protein; SPTR: A5G619 Cache, type 2 domain protein.
  
     0.465
Deba_0395
Nucleotide sugar dehydrogenase; COGs: COG0677 UDP-N-acetyl-D-mannosaminuronate dehydrogenase; InterProIPR001732:IPR014026:IPR014027:IPR008927:IPR 016040:IPR017476; KEGG: dal:Dalk_1698 nucleotide sugar dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase dimerisation; UDP-glucose/GDP-mannose dehydrogenase; UDP-glucose/GDP-mannose dehydrogenase; SPTR: B8FEJ1 Nucleotide sugar dehydrogenase; TIGRFAM: nucleotide sugar dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; UDP-glucose/GDP-mannose dehydrogenase family, central domain; UDP-glucose/GDP-mann [...]
 
    0.460
Deba_0175
COGs: COG2049 Allophanate hydrolase subunit 1; InterPro IPR003833:IPR003778:IPR010016; KEGG: sth:STH379 putative allophanate hydrolase; PFAM: Allophanate hydrolase subunit 1; Allophanate hydrolase subunit 2; SMART: Allophanate hydrolase subunit 1; Allophanate hydrolase subunit 2; SPTR: Q67SH9 Putative allophanate hydrolase; PFAM: Metallo-beta-lactamase superfamily; Allophanate hydrolase subunit 2; Allophanate hydrolase subunit 1; TIGRFAM: conserved hypothetical protein TIGR00370; biotin-dependent carboxylase uncharacterized domain.
  
  
 0.457
Deba_1372
COGs: COG0247 Fe-S oxidoreductase; InterPro IPR004017:IPR017900; KEGG: dol:Dole_0770 hypothetical protein; PFAM: protein of unknown function DUF224 cysteine-rich region domain protein; SPTR: A8ZVB9 Putative uncharacterized protein; PFAM: Cysteine-rich domain.
  
     0.419
Deba_2480
Anti-sigma-factor antagonist; InterPro IPR003658:IPR002645; KEGG: sfu:Sfum_1506 anti-sigma-factor antagonist; PFAM: Sulfate transporter/antisigma-factor antagonist STAS; SPTR: A0LIE3 Anti-sigma-factor antagonist; TIGRFAM: anti-anti-sigma factor; PFAM: STAS domain; TIGRFAM: anti-anti-sigma factor.
  
     0.408
Your Current Organism:
Desulfarculus baarsii
NCBI taxonomy Id: 644282
Other names: D. baarsii DSM 2075, Desulfarculus baarsii 2st 14, Desulfarculus baarsii DSM 2075, Desulfarculus baarsii str. DSM 2075, Desulfarculus baarsii strain DSM 2075
Server load: low (32%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.