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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
htpXPeptidase M48 Ste24p; COGs: COG0501 Zn-dependent protease with chaperone function; InterPro IPR001915; KEGG: glo:Glov_0554 peptidase M48 Ste24p; PFAM: peptidase M48 Ste24p; SPTR: B3E370 Peptidase M48 Ste24p; PFAM: Peptidase family M48; Belongs to the peptidase M48B family. (320 aa)    
Predicted Functional Partners:
Deba_0408
Peptidase S1 and S6 chymotrypsin/Hap; COGs: COG0265 Trypsin-like serine protease typically periplasmic contain C-terminal PDZ domain; InterPro IPR001254:IPR001478:IPR009003:IPR001940; KEGG: dde:Dde_3776 PDZ/DHR/GLGF; PFAM: peptidase S1 and S6 chymotrypsin/Hap; PDZ/DHR/GLGF domain protein; SMART: PDZ/DHR/GLGF domain protein; SPTR: Q30US8 PDZ/DHR/GLGF; PFAM: Trypsin; PDZ domain (Also known as DHR or GLGF); TIGRFAM: periplasmic serine protease, Do/DeqQ family.
  
  
 0.826
Deba_0406
Methyltransferase type 11; COGs: COG2226 Methylase involved in ubiquinone/menaquinone biosynthesis; InterPro IPR013216; KEGG: dal:Dalk_0098 methyltransferase type 11; PFAM: Methyltransferase type 11; SPTR: B8FKJ3 Methyltransferase type 11; PFAM: Methyltransferase domain.
       0.693
grpE
GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]
  
  
 0.623
Deba_3205
Protein of unknown function UPF0005; COGs: COG0670 Integral membrane protein interacts with FtsH; InterPro IPR006214; KEGG: dol:Dole_1724 hypothetical protein; PFAM: protein of unknown function UPF0005; SPTR: A9A0M8 Putative uncharacterized protein; PFAM: Uncharacterised protein family UPF0005; Belongs to the BI1 family.
  
  
 0.575
ftsH
ATP-dependent metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.
  
 
 0.569
ftsH-2
ATP-dependent metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.
  
 
 0.563
clpB
ATP-dependent chaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family.
  
  
 0.561
Deba_2312
COGs: COG1868 Flagellar motor switch protein; InterPro IPR001543:IPR001689; KEGG: dma:DMR_22580 flagellar motor switch protein FliM; PFAM: flagellar motor switch protein FliM; surface presentation of antigens (SPOA) protein; SPTR: C4XSQ7 Flagellar motor switch protein FliM; TIGRFAM: flagellar motor switch protein FliM; PFAM: Surface presentation of antigens (SPOA); Flagellar motor switch protein FliM; TIGRFAM: flagellar motor switch protein FliM.
    
   0.515
Deba_0405
Cyclase family protein; COGs: COG1878 metal-dependent hydrolase; InterPro IPR007325:IPR000169; KEGG: dal:Dalk_1541 cyclase family protein; PFAM: cyclase family protein; SPTR: B8FAE3 Cyclase family protein; PFAM: Putative cyclase.
       0.492
lon
ATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
   
 
 0.478
Your Current Organism:
Desulfarculus baarsii
NCBI taxonomy Id: 644282
Other names: D. baarsii DSM 2075, Desulfarculus baarsii 2st 14, Desulfarculus baarsii DSM 2075, Desulfarculus baarsii str. DSM 2075, Desulfarculus baarsii strain DSM 2075
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