Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Deba_0600Beta-lactamase domain protein; COGs: COG1234 Metal-dependent hydrolase of the beta-lactamase superfamily III; KEGG: dal:Dalk_3435 beta-lactamase domain protein; SPTR: B8FLH7 Beta-lactamase domain protein; PFAM: Metallo-beta-lactamase superfamily. (265 aa)    
Predicted Functional Partners:
Deba_0601
PHP domain protein; COGs: COG0613 metal-dependent phosphoesterase (PHP family); InterPro IPR004013:IPR016195:IPR003141; KEGG: chy:CHY_2227 phosphotransferase domain-containing protein; PFAM: PHP domain protein; SMART: phosphoesterase PHP domain protein; SPTR: Q3A9Z4 PHP domain protein; PFAM: PHP domain.
     
 0.800
Deba_0602
COGs: COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains; InterPro IPR001789:IPR011006; KEGG: sat:SYN_01292 response regulator; PFAM: response regulator receiver; SMART: response regulator receiver; SPTR: Q2LX20 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; PFAM: Response regulator receiver domain.
       0.689
Deba_1434
COGs: COG0557 Exoribonuclease R; InterPro IPR001900; KEGG: dal:Dalk_3638 exoribonuclease II; PFAM: ribonuclease II; PRIAM: Exoribonuclease II; SPTR: B8FGU6 Exoribonuclease II; PFAM: RNB domain; TIGRFAM: VacB and RNase II family 3'-5' exoribonucleases.
  
  
 0.516
Deba_1209
Polynucleotide adenylyltransferase region; COGs: COG0617 tRNA nucleotidyltransferase/poly(A) polymerase; InterPro IPR001667:IPR003156:IPR000644:IPR002646; KEGG: sfu:Sfum_0679 polynucleotide adenylyltransferase region; PFAM: Polynucleotide adenylyltransferase region; CBS domain containing protein; phosphoesterase RecJ domain protein; phosphoesterase DHHA1; SMART: CBS domain containing protein; SPTR: A0LG26 Polynucleotide adenylyltransferase region; PFAM: DHH family; DHHA1 domain; CBS domain; Poly A polymerase head domain; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.
  
  
 0.508
Deba_0598
GAF sensor signal transduction histidine kinase; COGs: COG2205 Osmosensitive K+ channel histidine kinase; InterProIPR003018:IPR003661:IPR003594:IPR004358:IPR 005467; KEGG: dal:Dalk_2141 GAF sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; GAF domain protein; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; GAF domain protein; histidine kinase A domain protein; SPTR: Q1NPH4 Sensor protein; PFAM: GAF domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain.
  
    0.504
Deba_0597
COGs: COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; InterProIPR001789:IPR013105:IPR011717:IPR001440:IPR 011006:IPR019734:IPR011990:IPR013026:IPR005829; KEGG: hch:HCH_04305 FOG: CheY-like receiver; PFAM: response regulator receiver; Tetratricopeptide TPR_2 repeat protein; Tetratricopeptide TPR_4; TPR repeat-containing protein; SMART: response regulator receiver; Tetratricopeptide repeat; SPTR: A6F3F5 CheY-like receiver protein; PFAM: Response regulator receiver domain; Tetratricopeptide repeat.
       0.491
guaA
GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP.
  
    0.488
Deba_3298
Adenylate/guanylate cyclase with Chase sensor; COGs: COG2114 Adenylate cyclase family 3 (some protein contain HAMP domain); InterPro IPR001054:IPR007890; KEGG: sfu:Sfum_2382 adenylate/guanylate cyclase; PFAM: CHASE2 domain protein; adenylyl cyclase class-3/4/guanylyl cyclase; SMART: adenylyl cyclase class-3/4/guanylyl cyclase; SPTR: A0LKW1 Adenylate/guanylate cyclase; PFAM: Adenylate and Guanylate cyclase catalytic domain; CHASE2 domain.
     
 0.486
Deba_0604
ABC-3 protein; COGs: COG1108 ABC-type Mn2+/Zn2+ transport systems permease components; InterPro IPR001626; KEGG: noc:Noc_2421 ABC Mn2+/Zn2+ transporter,inner membrane subunit; PFAM: ABC-3 protein; SPTR: C5SCP6 ABC-3 protein; PFAM: ABC 3 transport family.
       0.482
Deba_0599
Protein of unknown function DUF88; COGs: COG1432 conserved hypothetical protein; InterPro IPR002790; KEGG: hmo:HM1_0800 hypothetical protein; PFAM: protein of unknown function DUF88; SPTR: B0TB28 Putative uncharacterized protein; PFAM: Protein of unknown function DUF88.
     
 0.478
Your Current Organism:
Desulfarculus baarsii
NCBI taxonomy Id: 644282
Other names: D. baarsii DSM 2075, Desulfarculus baarsii 2st 14, Desulfarculus baarsii DSM 2075, Desulfarculus baarsii str. DSM 2075, Desulfarculus baarsii strain DSM 2075
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