Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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lpxCUDP-3-0-acyl N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. (306 aa)    
Predicted Functional Partners:
lpxD
UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
 
 
 0.987
lpxA
acyl-(acyl-carrier-protein)--UDP-N-acetylglucosa mineO-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
 
 
 0.986
fabZ
Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
    
 0.943
Deba_3124
KpsF/GutQ family protein; COGs: COG0794 sugar phosphate isomerase involved in capsule formation; InterPro IPR004800:IPR001347:IPR000644; KEGG: dol:Dole_2110 KpsF/GutQ family protein; PFAM: sugar isomerase (SIS); CBS domain containing protein; PRIAM: Arabinose-5-phosphate isomerase; SPTR: A8ZTY1 KpsF/GutQ family protein; TIGRFAM: KpsF/GutQ family protein; PFAM: CBS domain; SIS domain; TIGRFAM: KpsF/GutQ family protein; Belongs to the SIS family. GutQ/KpsF subfamily.
 
   
 0.882
lpxB
lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
 
   
 0.872
lpxK
Tetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
 
   
 0.865
kdsB
3-deoxy-D-manno- octulosonatecytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
 
   
 0.846
Deba_2093
COGs: COG1560 Lauroyl/myristoyl acyltransferase; InterPro IPR004960; KEGG: sfu:Sfum_0376 lipid A biosynthesis acyltransferase; PFAM: lipid A biosynthesis acyltransferase; SPTR: A0LF74 Lipid A biosynthesis acyltransferase; PFAM: Bacterial lipid A biosynthesis acyltransferase.
 
   
 0.833
Deba_0597
COGs: COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; InterProIPR001789:IPR013105:IPR011717:IPR001440:IPR 011006:IPR019734:IPR011990:IPR013026:IPR005829; KEGG: hch:HCH_04305 FOG: CheY-like receiver; PFAM: response regulator receiver; Tetratricopeptide TPR_2 repeat protein; Tetratricopeptide TPR_4; TPR repeat-containing protein; SMART: response regulator receiver; Tetratricopeptide repeat; SPTR: A6F3F5 CheY-like receiver protein; PFAM: Response regulator receiver domain; Tetratricopeptide repeat.
   
 
 0.823
kdsA
2-dehydro-3-deoxyphosphooctonate aldolase; COGs: COG2877 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase; InterPro IPR006218:IPR013785:IPR006269; KEGG: dsa:Desal_2260 2-dehydro-3-deoxyphosphooctonate aldolase; PFAM: DAHP synthetase I/KDSA; PRIAM: 3-deoxy-8-phosphooctulonate synthase; SPTR: C6BWN6 2-dehydro-3-deoxyphosphooctonate aldolase; TIGRFAM: 2-dehydro-3-deoxyphosphooctonate aldolase; PFAM: DAHP synthetase I family; TIGRFAM: 3-deoxy-8-phosphooctulonate synthase.
 
  
 0.823
Your Current Organism:
Desulfarculus baarsii
NCBI taxonomy Id: 644282
Other names: D. baarsii DSM 2075, Desulfarculus baarsii 2st 14, Desulfarculus baarsii DSM 2075, Desulfarculus baarsii str. DSM 2075, Desulfarculus baarsii strain DSM 2075
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