STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Deba_0710COGs: COG0427 Acetyl-CoA hydrolase; InterPro IPR003702; KEGG: mhu:Mhun_1561 acetyl-CoA hydrolase/transferase; PFAM: acetyl-CoA hydrolase/transferase; SPTR: Q2FRF0 Acetyl-CoA hydrolase/transferase; PFAM: Acetyl-CoA hydrolase/transferase N-terminal domain. (433 aa)    
Predicted Functional Partners:
sucC
succinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
   
 0.955
sucD
succinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
   
 0.948
icmF
methylmalonyl-CoA mutase, large subunit; Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly.
  
  
 0.780
Deba_0711
Major facilitator superfamily MFS_1; COGs: COG2814 Arabinose efflux permease; InterPro IPR016196:IPR001958:IPR011701:IPR005829; KEGG: drt:Dret_2117 major facilitator superfamily MFS_1; PFAM: major facilitator superfamily MFS_1; SPTR: C8X4C7 Major facilitator superfamily MFS_1; PFAM: Major Facilitator Superfamily.
       0.634
Deba_1491
COGs: COG0372 Citrate synthase; InterProIPR002020:IPR019810:IPR016142:IPR010953:IPR 016141; KEGG: dal:Dalk_4974 citrate synthase I; PFAM: Citrate synthase; PRIAM: Citrate (Si)-synthase; SPTR: B8FDL5 Citrate synthase; TIGRFAM: citrate synthase I; PFAM: Citrate synthase; TIGRFAM: citrate synthase I (hexameric type); Belongs to the citrate synthase family.
  
 
 0.601
Deba_0709
COGs: COG1454 Alcohol dehydrogenase class IV; InterPro IPR001670:IPR018211; KEGG: tai:Taci_1279 iron-containing alcohol dehydrogenase; PFAM: iron-containing alcohol dehydrogenase; SPTR: Q1NLZ5 Iron-containing alcohol dehydrogenase; PFAM: Iron-containing alcohol dehydrogenase.
  
  
 0.555
Deba_0883
Cobalamin B12-binding domain protein; COGs: COG2185 Methylmalonyl-CoA mutase C-terminal domain/subunit (cobalamin-binding); InterPro IPR006159:IPR006158; KEGG: pth:PTH_1362 methylmalonyl-CoA mutase C-terminal domain-containing protein; PFAM: cobalamin B12-binding domain protein; SPTR: A5D2I7 Methylmalonyl-CoA mutase, C-terminal domain/subunit; PFAM: B12 binding domain; TIGRFAM: methylmalonyl-CoA mutase C-terminal domain.
  
  
 0.486
Deba_3134
Short-chain dehydrogenase/reductase SDR; COGs: COG1028 Dehydrogenase with different specificities (related to short-chain alcohol dehydrogenase); InterProIPR016040:IPR016083:IPR002539:IPR002198:IPR 003033:IPR002347; KEGG: dal:Dalk_3192 short-chain dehydrogenase/reductase SDR; PFAM: short-chain dehydrogenase/reductase SDR; MaoC domain protein dehydratase; Sterol-binding domain protein; SPTR: B8FGH3 Short-chain dehydrogenase/reductase SDR; PFAM: MaoC like domain; short chain dehydrogenase; SCP-2 sterol transfer family.
  
 
 0.486
eno
Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
   
  
 0.482
Deba_1380
Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family.
     
 0.408
Your Current Organism:
Desulfarculus baarsii
NCBI taxonomy Id: 644282
Other names: D. baarsii DSM 2075, Desulfarculus baarsii 2st 14, Desulfarculus baarsii DSM 2075, Desulfarculus baarsii str. DSM 2075, Desulfarculus baarsii strain DSM 2075
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