STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
Deba_0803COGs: COG2176 DNA polymerase III alpha subunit (gram-positive type); InterPro IPR006054:IPR006055:IPR012337:IPR013520; KEGG: cte:CT1039 DNA polymerase III, epsilon subunit; PFAM: Exonuclease RNase T and DNA polymerase III; PRIAM: DNA-directed DNA polymerase; SMART: Exonuclease; SPTR: Q8KDK8 DNA polymerase III, epsilon subunit; TIGRFAM: DNA polymerase III, epsilon subunit; PFAM: Exonuclease; TIGRFAM: exonuclease, DNA polymerase III, epsilon subunit family. (240 aa)    
Predicted Functional Partners:
Deba_0802
Putative CBS domain and cyclic nucleotide-regulated nucleotidyltransferase; COGs: COG2905 signal-transduction protein containing cAMP-binding and CBS domains; InterProIPR000644:IPR000595:IPR014710:IPR018490:IPR 005105:IPR018821; KEGG: tye:THEYE_A0033 putative nucleotidyltransferase family; PFAM: protein of unknown function DUF294 nucleotidyltransferase putative; CBS domain containing protein; cyclic nucleotide-binding; Domain of unknown function DUF294, putative nucleotidyltransferase substrate-binding; SMART: CBS domain containing protein; SPTR: B5YGV7 Putative nucleotidyltransferase [...]
 
   
 0.948
Deba_0246
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
    
 0.936
Deba_2373
COGs: COG0587 DNA polymerase III alpha subunit; InterProIPR016195:IPR003141:IPR004013:IPR011708:IPR 004365:IPR004805; KEGG: pca:Pcar_1222 DNA polymerase III, alpha subunit; PFAM: DNA polymerase III alpha subunit; PHP domain protein; nucleic acid binding OB-fold tRNA/helicase-type; PRIAM: DNA-directed DNA polymerase; SMART: phosphoesterase PHP domain protein; SPTR: Q3A586 DNA polymerase III, alpha subunit; TIGRFAM: DNA polymerase III, alpha subunit; PFAM: Bacterial DNA polymerase III alpha subunit; PHP domain; OB-fold nucleic acid binding domain; TIGRFAM: DNA-directed DNA polymerase III [...]
    
 0.926
Deba_1414
COGs: COG1466 DNA polymerase III delta subunit; InterPro IPR010372:IPR005790:IPR008921; KEGG: gur:Gura_3132 DNA polymerase III, delta subunit; PFAM: DNA polymerase III delta; SPTR: A5G675 DNA polymerase III, delta subunit; TIGRFAM: DNA polymerase III, delta subunit; PFAM: DNA polymerase III, delta subunit; TIGRFAM: DNA polymerase III, delta subunit.
    
 0.921
Deba_0233
COGs: COG2812 DNA polymerase III gamma/tau subunits; KEGG: afw:Anae109_2451 DNA polymerase III, delta prime subunit; SPTR: A7HD56 DNA polymerase III, delta prime subunit; TIGRFAM: DNA polymerase III, delta' subunit.
  
 0.919
dnaX
DNA polymerase III, subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
  
 0.919
Deba_0005
COGs: COG2927 DNA polymerase III chi subunit; InterPro IPR007459; KEGG: pca:Pcar_1548 DNA polymerase III, chi subunit; PFAM: DNA polymerase III chi subunit HolC; SPTR: Q3A4B4 DNA polymerase III, chi subunit; PFAM: DNA polymerase III chi subunit, HolC.
     
  0.900
birA
biotin/acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.
  
    0.523
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
   
 
 0.522
Deba_0801
Thioesterase putative; InterPro IPR006683:IPR012660; KEGG: pmy:Pmen_0555 hypothetical protein; PFAM: Thioesterase putative; thioesterase superfamily protein; SPTR: A4XPQ9 Putative uncharacterized protein; PFAM: Thioesterase superfamily; TIGRFAM: uncharacterized domain 1; thioesterase domain, putative.
       0.515
Your Current Organism:
Desulfarculus baarsii
NCBI taxonomy Id: 644282
Other names: D. baarsii DSM 2075, Desulfarculus baarsii 2st 14, Desulfarculus baarsii DSM 2075, Desulfarculus baarsii str. DSM 2075, Desulfarculus baarsii strain DSM 2075
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