STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
nadENAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (565 aa)    
Predicted Functional Partners:
nadD
Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
  
 
 0.966
nadK
ATP-NAD/AcoX kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
    
 0.962
cobB
Silent information regulator protein Sir2; COGs: COG0846 NAD-dependent protein deacetylase SIR2 family; InterPro IPR003000; KEGG: sfu:Sfum_3557 silent information regulator protein Sir2; PFAM: Silent information regulator protein Sir2; SPTR: A0LP75 Silent information regulator protein Sir2; PFAM: Sir2 family; Belongs to the sirtuin family. Class III subfamily.
   
 0.957
Deba_2660
Silent information regulator protein Sir2; COGs: COG0846 NAD-dependent protein deacetylase SIR2 family; InterPro IPR003000; KEGG: dal:Dalk_1098 silent information regulator protein Sir2; PFAM: Silent information regulator protein Sir2; SPTR: C8QW70 Silent information regulator protein Sir2; PFAM: Sir2 family.
   
 0.957
Deba_1153
COGs: COG0518 GMP synthase - Glutamine amidotransferase domain; InterPro IPR000991:IPR017926; KEGG: cja:CJA_0967 conserved proteinconserved protein; PFAM: glutamine amidotransferase class-I; SPTR: B3PLE3 Conserved proteinconserved protein; PFAM: Glutamine amidotransferase class-I.
 
   
 0.926
Deba_0469
NAD(+) diphosphatase; COGs: COG2816 NTP pyrophosphohydrolase containing a Zn-finger probably nucleic-acid-binding; InterProIPR015375:IPR015376:IPR000086:IPR015797:IPR 020084; KEGG: scl:sce4370 NADH pyrophosphatase; PFAM: NUDIX hydrolase; NADH pyrophosphatase-like; Zinc ribbon NADH pyrophosphatase; PRIAM: NAD(+) diphosphatase; SPTR: A9F2Z4 NADH pyrophosphatase; PFAM: NADH pyrophosphatase zinc ribbon domain; NUDIX domain.
  
 
 0.918
Deba_0953
MazG family protein; COGs: COG3956 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain; InterPro IPR004518:IPR011551; KEGG: scl:sce4803 hypothetical protein; PFAM: MazG nucleotide pyrophosphohydrolase; SPTR: A9FF91 Putative uncharacterized protein mazG; TIGRFAM: MazG family protein; PFAM: MazG nucleotide pyrophosphohydrolase domain; TIGRFAM: MazG family protein.
    
  0.903
Deba_1152
COGs: COG0069 Glutamate synthase domain 2; InterProIPR002489:IPR000583:IPR006982:IPR002932:IPR 013785:IPR017932; KEGG: ttr:Tter_0474 glutamate synthase (ferredoxin); PFAM: ferredoxin-dependent glutamate synthase; glutamine amidotransferase class-II; glutamate synthase; glutamate synthase alpha subunit domain protein; PRIAM: Glutamate synthase (ferredoxin); SPTR: D1CEN9 Glutamate synthase (Ferredoxin); PFAM: Conserved region in glutamate synthase; GXGXG motif; Glutamate synthase central domain; Glutamine amidotransferases class-II.
     
 0.811
Deba_0844
Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family.
  
  
 0.801
Deba_0479
COGs: COG0077 Prephenate dehydratase; InterProIPR020822:IPR001086:IPR002912:IPR008242:IPR 002701:IPR018528; KEGG: pca:Pcar_1887 chorismate mutase-P and prephenate dehydratase; PFAM: prephenate dehydratase; Chorismate mutase, type II; amino acid-binding ACT domain protein; SPTR: Q1K0T9 Chorismate mutase; PFAM: Prephenate dehydratase; ACT domain; Chorismate mutase type II.
  
  
 0.795
Your Current Organism:
Desulfarculus baarsii
NCBI taxonomy Id: 644282
Other names: D. baarsii DSM 2075, Desulfarculus baarsii 2st 14, Desulfarculus baarsii DSM 2075, Desulfarculus baarsii str. DSM 2075, Desulfarculus baarsii strain DSM 2075
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