STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
sbcDNuclease SbcCD, D subunit; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family. (379 aa)    
Predicted Functional Partners:
Deba_1161
SMC domain protein; COGs: COG0419 ATPase involved in DNA repair; InterPro IPR003395:IPR018271; KEGG: reh:H16_B0196 DNA repair exonuclease, SbcC; PFAM: SMC domain protein; SPTR: Q0K4S7 DNA repair exonuclease, SbcC; TIGRFAM: exonuclease SbcC.
 0.999
Deba_0999
SMC domain protein; COGs: COG0419 ATPase involved in DNA repair; InterPro IPR003395; KEGG: ppf:Pput_2963 ATPase involved in DNA repair-like protein; PFAM: SMC domain protein; SPTR: A5W4N1 ATPase involved in DNA repair-like protein.
  
 0.994
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 0.993
Deba_2969
KEGG: bcv:Bcav_3932 hypothetical protein; SPTR: C5C533 Putative uncharacterized protein.
    
 0.922
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
 0.912
Deba_0036
Sulphate transporter; COGs: COG0659 Sulfate permease and related transporter (MFS superfamily); InterPro IPR011547:IPR002645; KEGG: dde:Dde_3641 sulfate permease; PFAM: sulphate transporter; Sulfate transporter/antisigma-factor antagonist STAS; SPTR: Q30V62 Sulfate permease; PFAM: Sulfate transporter family; STAS domain; TIGRFAM: high affinity sulphate transporter 1.
  
   0.909
Deba_2577
Helicase domain protein; COGs: COG0553 Superfamily II DNA/RNA helicase SNF2 family; InterPro IPR014001:IPR001650:IPR000330:IPR014021; KEGG: sfu:Sfum_3846 helicase domain-containing protein; PFAM: helicase domain protein; SNF2-related protein; SMART: DEAD-like helicase; helicase domain protein; SPTR: A0LQ13 Helicase domain protein; manually curated; PFAM: Helicase conserved C-terminal domain; SNF2 family N-terminal domain.
  
 
 0.886
Deba_2746
Helicase c2; COGs: COG1199 Rad3-related DNA helicase; InterPro IPR014001:IPR006555:IPR014013:IPR001650; KEGG: noc:Noc_1364 helicase C2; SMART: helicase c2; DEAD-like helicase; SPTR: Q3JBD8 Helicase c2; PFAM: DEAD_2; DEAD/DEAH box helicase.
   
 0.879
recA
recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 0.818
Deba_1163
COGs: COG0624 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylase; InterPro IPR011650:IPR002933:IPR010182; KEGG: dvm:DvMF_0550 diaminopimelate aminotransferase; PFAM: peptidase M20; peptidase dimerisation domain protein; SPTR: B8DKS8 Peptidase M20; TIGRFAM: acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; PFAM: Peptidase family M20/M25/M40; Peptidase dimerisation domain; TIGRFAM: acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase.
  
    0.783
Your Current Organism:
Desulfarculus baarsii
NCBI taxonomy Id: 644282
Other names: D. baarsii DSM 2075, Desulfarculus baarsii 2st 14, Desulfarculus baarsii DSM 2075, Desulfarculus baarsii str. DSM 2075, Desulfarculus baarsii strain DSM 2075
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