STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (270 aa)    
Predicted Functional Partners:
Deba_0009
COGs: COG0506 Proline dehydrogenase; InterPro IPR002872; KEGG: bba:Bd1251 1-pyrroline-5 carboxylate dehydrogenase; PFAM: Proline dehydrogenase; SPTR: B4VMU2 Delta-1-pyrroline-5-carboxylate dehydrogenase, putative; PFAM: Proline dehydrogenase.
   
 0.936
Deba_0025
Proline-specific peptidase; COGs: COG0596 hydrolase or acyltransferase (alpha/beta hydrolase superfamily); InterPro IPR000073:IPR005945:IPR002410; KEGG: mpl:Mpal_1914 proline-specific peptidase; PFAM: alpha/beta hydrolase fold; SPTR: B8GKS2 Proline-specific peptidase; TIGRFAM: proline-specific peptidase; PFAM: alpha/beta hydrolase fold; TIGRFAM: proline-specific peptidases, Bacillus coagulans-type subfamily; Belongs to the peptidase S33 family.
    
 0.906
proB
Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
 
 
 0.822
proA
Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family.
 
 
 0.801
Deba_1212
Putative sigma54 specific transcriptional regulator; COGs: COG3829 Transcriptional regulator containing PAS AAA-type ATPase and DNA-binding domains; InterPro IPR002078:IPR003593; KEGG: aav:Aave_0172 two component, sigma54 specific, fis family transcriptional regulator; PFAM: sigma-54 factor interaction domain-containing protein; SMART: AAA ATPase; SPTR: A1TIJ6 Two component, sigma54 specific, transcriptional regulator, Fis family; PFAM: Sigma-54 interaction domain.
       0.773
Deba_1209
Polynucleotide adenylyltransferase region; COGs: COG0617 tRNA nucleotidyltransferase/poly(A) polymerase; InterPro IPR001667:IPR003156:IPR000644:IPR002646; KEGG: sfu:Sfum_0679 polynucleotide adenylyltransferase region; PFAM: Polynucleotide adenylyltransferase region; CBS domain containing protein; phosphoesterase RecJ domain protein; phosphoesterase DHHA1; SMART: CBS domain containing protein; SPTR: A0LG26 Polynucleotide adenylyltransferase region; PFAM: DHH family; DHHA1 domain; CBS domain; Poly A polymerase head domain; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.
       0.711
Deba_1211
Peptidase M24; COGs: COG0006 Xaa-Pro aminopeptidase; InterPro IPR001714:IPR000994:IPR000587; KEGG: sfu:Sfum_0169 peptidase M24; PFAM: peptidase M24; creatinase; SPTR: Q1NY97 Peptidase M24; PFAM: Metallopeptidase family M24; Creatinase/Prolidase N-terminal domain.
  
 
 0.690
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
     
 0.679
Deba_3024
DNA internalization-related competence protein ComEC/Rec2; COGs: COG2333 hydrolase (metallo-beta-lactamase superfamily); InterPro IPR004477:IPR004797; KEGG: dal:Dalk_2782 DNA internalization-related competence protein ComEC/Rec2; PFAM: ComEC/Rec2-related protein; SPTR: B8FKV2 DNA internalization-related competence protein ComEC/Rec2; TIGRFAM: DNA internalization-related competence protein ComEC/Rec2; ComEC/Rec2-related protein; PFAM: Competence protein; Metallo-beta-lactamase superfamily; TIGRFAM: ComEC/Rec2-related protein; DNA internalization-related competence protein ComEC/Rec2.
     
 0.660
Deba_1152
COGs: COG0069 Glutamate synthase domain 2; InterProIPR002489:IPR000583:IPR006982:IPR002932:IPR 013785:IPR017932; KEGG: ttr:Tter_0474 glutamate synthase (ferredoxin); PFAM: ferredoxin-dependent glutamate synthase; glutamine amidotransferase class-II; glutamate synthase; glutamate synthase alpha subunit domain protein; PRIAM: Glutamate synthase (ferredoxin); SPTR: D1CEN9 Glutamate synthase (Ferredoxin); PFAM: Conserved region in glutamate synthase; GXGXG motif; Glutamate synthase central domain; Glutamine amidotransferases class-II.
     
 0.621
Your Current Organism:
Desulfarculus baarsii
NCBI taxonomy Id: 644282
Other names: D. baarsii DSM 2075, Desulfarculus baarsii 2st 14, Desulfarculus baarsii DSM 2075, Desulfarculus baarsii str. DSM 2075, Desulfarculus baarsii strain DSM 2075
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