STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
Deba_1297Phosphodiesterase, MJ0936 family; COGs: COG0622 phosphoesterase; InterPro IPR004843:IPR000979; KEGG: dal:Dalk_0913 phosphodiesterase, MJ0936 family; PFAM: metallophosphoesterase; SPTR: Q2YZQ0 Putative uncharacterized protein; TIGRFAM: phosphodiesterase, MJ0936 family; PFAM: Calcineurin-like phosphoesterase; TIGRFAM: phosphoesterase, MJ0936 family. (159 aa)    
Predicted Functional Partners:
Deba_1296
ApbE family lipoprotein; COGs: COG2122 conserved hypothetical protein; InterPro IPR003374:IPR007183; KEGG: sfu:Sfum_2124 hypothetical protein; PFAM: ApbE family lipoprotein; SPTR: A0LK55 Putative uncharacterized protein; PFAM: ApbE family.
 
     0.807
Deba_1298
Histidine triad (HIT) protein; COGs: COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolase; InterPro IPR001310:IPR011151:IPR011146; KEGG: sfu:Sfum_2126 histidine triad (HIT) protein; PFAM: histidine triad (HIT) protein; SPTR: A0LK57 Histidine triad (HIT) protein; PFAM: HIT domain.
  
    0.807
Deba_1299
KEGG: drt:Dret_1341 hypothetical protein; SPTR: C8X2I2 Putative uncharacterized protein; PFAM: Protein of unknown function (DUF1049).
       0.756
lapB
TPR repeat-containing protein; Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane; Belongs to the LapB family.
       0.753
mutS
DNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.
  
    0.615
Deba_0490
Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
  
  
 0.601
Deba_1302
Cell wall hydrolase/autolysin; COGs: COG0860 N-acetylmuramoyl-L-alanine amidase; InterPro IPR002508; KEGG: drt:Dret_0142 N-acetylmuramoyl-L-alanine amidase; PFAM: cell wall hydrolase/autolysin; SMART: cell wall hydrolase/autolysin; SPTR: C8WZG9 N-acetylmuramoyl-L-alanine amidase; PFAM: N-acetylmuramoyl-L-alanine amidase; Localisation of periplasmic protein complexes.
  
    0.558
Deba_3097
Tetratricopeptide TPR_2 repeat protein; InterProIPR001440:IPR013105:IPR019734:IPR013026:IPR 011990; KEGG: dat:HRM2_20780 tetratricopeptide (TPR) domain protein; PFAM: Tetratricopeptide TPR_2 repeat protein; TPR repeat-containing protein; SPTR: C0QDB3 Tetratricopeptide (TPR) domain protein; PFAM: ChAPs (Chs5p-Arf1p-binding proteins); TIGRFAM: putative PEP-CTERM system TPR-repeat lipoprotein.
   
   0.492
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
       0.475
Your Current Organism:
Desulfarculus baarsii
NCBI taxonomy Id: 644282
Other names: D. baarsii DSM 2075, Desulfarculus baarsii 2st 14, Desulfarculus baarsii DSM 2075, Desulfarculus baarsii str. DSM 2075, Desulfarculus baarsii strain DSM 2075
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