Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Score
Deba_1443Protein of unknown function DUF218; COGs: COG1434 conserved hypothetical protein; InterPro IPR003848; KEGG: pwa:Pecwa_2047 protein of unknown function DUF218; PFAM: protein of unknown function DUF218; SPTR: D0KBS4 Putative uncharacterized protein; PFAM: DUF218 domain. (270 aa)    
Predicted Functional Partners:
mnmG
Glucose inhibited division protein A; NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34; Belongs to the MnmG family.
       0.773
Deba_1441
CDP-alcohol phosphatidyltransferase; COGs: COG0558 Phosphatidylglycerophosphate synthase; InterPro IPR000462; KEGG: bcv:Bcav_2296 CDP-alcohol phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase; SPTR: C5BVU6 CDP-alcohol phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
       0.513
Deba_1440
TPR repeat-containing protein; COGs: COG3063 Tfp pilus assembly protein PilF; InterPro IPR001440:IPR019734:IPR013026:IPR011990; KEGG: dsa:Desal_2816 tetratricopeptide TPR_2 repeat protein; PFAM: TPR repeat-containing protein; SPTR: C6BZZ7 Tetratricopeptide TPR_2 repeat protein; PFAM: Tetratricopeptide repeat.
       0.510
hisH
Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
       0.504
hisF
Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
       0.503
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
       0.480
Deba_1437
Bifunctional GlmU protein; COGs: COG1207 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains); InterPro IPR001451:IPR011004; KEGG: dps:DP2923 bifunctional GlmU protein; SPTR: C0GCM6 Bifunctional GlmU protein.
       0.440
Deba_0005
COGs: COG2927 DNA polymerase III chi subunit; InterPro IPR007459; KEGG: pca:Pcar_1548 DNA polymerase III, chi subunit; PFAM: DNA polymerase III chi subunit HolC; SPTR: Q3A4B4 DNA polymerase III, chi subunit; PFAM: DNA polymerase III chi subunit, HolC.
 
     0.427
Deba_1436
COGs: COG0438 Glycosyltransferase; KEGG: csa:Csal_2123 glycosyl transferase, group 1; SPTR: A6G2P4 Glycosyl transferase, group 1; manually curated; PFAM: Glycosyl transferases group 1; Domain of unknown function (DUF3524).
       0.419
lipB-2
Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives; Belongs to the LipB family.
       0.416
Your Current Organism:
Desulfarculus baarsii
NCBI taxonomy Id: 644282
Other names: D. baarsii DSM 2075, Desulfarculus baarsii 2st 14, Desulfarculus baarsii DSM 2075, Desulfarculus baarsii str. DSM 2075, Desulfarculus baarsii strain DSM 2075
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