Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Deba_1520NAD(P)-dependent iron-only hydrogenase iron-sulfur protein; InterPro IPR012336:IPR012335; KEGG: dat:HRM2_16520 NADP-reducing hydrogenase, subunit B; SPTR: C0QAH5 NADP-reducing hydrogenase, subunit B. (125 aa)    
Predicted Functional Partners:
Deba_1523
4Fe-4S ferredoxin iron-sulfur binding domain protein; COGs: COG4624 Iron only hydrogenase large subunit C-terminal domain; InterProIPR009016:IPR001450:IPR007202:IPR010766:IPR 017896:IPR017900; KEGG: dat:HRM2_16550 iron-sulfur binding hydrogenase; PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; Fe-S cluster domain protein; DRTGG domain protein; SPTR: C0QAH8 Iron-sulfur binding hydrogenase; PFAM: Iron only hydrogenase large subunit, C-terminal domain; DRTGG domain; Putative Fe-S cluster; 4Fe-4S binding domain.
 
 
 
 0.978
Deba_1521
Histidine kinase; COGs: COG0642 Signal transduction histidine kinase; InterPro IPR003594:IPR004358:IPR005467; KEGG: dat:HRM2_16530 sensory signal transduction histidine kinase (ATPase domain protein); PFAM: ATP-binding region ATPase domain protein; SMART: ATP-binding region ATPase domain protein; SPTR: B0PGV2 Putative uncharacterized protein; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase.
 
     0.904
Deba_1522
PHP domain protein; COGs: COG1379 conserved hypothetical protein; InterPro IPR003141:IPR016195:IPR004013; KEGG: dth:DICTH_0765 PHP domain, putative; PFAM: PHP domain protein; SMART: phosphoesterase PHP domain protein; SPTR: A1HP42 PHP C-terminal domain protein; PFAM: PHP domain.
 
   
 0.897
Deba_1525
KEGG: tai:Taci_0690 hypothetical protein; SPTR: D1B9H3 Putative uncharacterized protein; manually curated; PFAM: DRTGG domain.
 
     0.871
Deba_1524
COGs: COG2172 Anti-sigma regulatory factor (Ser/Thr protein kinase); InterPro IPR003594; KEGG: dth:DICTH_0761 anti-sigma regulatory factor; PFAM: ATP-binding region ATPase domain protein; SPTR: C1TN97 Anti-sigma regulatory factor (Ser/Thr protein kinase); PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase.
 
     0.868
Deba_1519
NADH dehydrogenase (quinone); COGs: COG1894 NADH:ubiquinone oxidoreductase NADH-binding (51 kD) subunit; InterProIPR012336:IPR011538:IPR019554:IPR019575:IPR 001450:IPR012335:IPR017896:IPR017900:IPR001949; KEGG: dat:HRM2_16600 NuoF; PFAM: Respiratory-chain NADH dehydrogenase domain 51 kDa subunit; Soluble ligand binding domain; NADH ubiquinone oxidoreductase, F subunit, iron sulphur binding; 4Fe-4S ferredoxin iron-sulfur binding domain protein; PRIAM: NADH dehydrogenase (quinone); SPTR: C0QAI3 NuoF; PFAM: NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; 4Fe-4S binding domain [...]
 
   
 0.858
Deba_1526
COGs: COG1905 NADH:ubiquinone oxidoreductase 24 kD subunit; InterPro IPR012336:IPR002023:IPR012335; KEGG: dat:HRM2_16590 NuoE; PFAM: NADH dehydrogenase (ubiquinone) 24 kDa subunit; SPTR: C0QAI2 NuoE; PFAM: Respiratory-chain NADH dehydrogenase 24 Kd subunit.
 
 
 0.767
Deba_0481
Molybdopterin oxidoreductase; COGs: COG3383 Uncharacterized anaerobic dehydrogenase; InterProIPR001041:IPR001450:IPR006963:IPR006656:IPR 009051:IPR017896:IPR017900:IPR006655; KEGG: dds:Ddes_1544 molybdopterin oxidoreductase Fe4s4 region; PFAM: molybdopterin oxidoreductase; molybdopterin oxidoreductase Fe4S4 region; ferredoxin; 4Fe-4S ferredoxin iron-sulfur binding domain protein; SPTR: B8J119 Molybdopterin oxidoreductase Fe4S4 region; PFAM: 2Fe-2S iron-sulfur cluster binding domain; Molybdopterin oxidoreductase; 4Fe-4S binding domain; Molybdopterin oxidoreductase Fe4S4 domain.
  
 
 0.596
Deba_0482
Molybdopterin oxidoreductase; COGs: COG3383 Uncharacterized anaerobic dehydrogenase; InterPro IPR006656:IPR006657:IPR009010; KEGG: sfu:Sfum_0031 molybdopterin oxidoreductase; PFAM: molybdopterin oxidoreductase; molydopterin dinucleotide-binding region; SPTR: A0LE82 Molybdopterin oxidoreductase; PFAM: Molybdopterin oxidoreductase; Molydopterin dinucleotide binding domain; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
  
 
 0.596
Deba_0488
Molybdopterin oxidoreductase; COGs: COG3383 Uncharacterized anaerobic dehydrogenase; InterProIPR001041:IPR019574:IPR001450:IPR006963:IPR 006656:IPR017896:IPR017900; KEGG: sfu:Sfum_3509 formate dehydrogenase, alpha subunit; PFAM: molybdopterin oxidoreductase; molybdopterin oxidoreductase Fe4S4 region; NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding; ferredoxin; 4Fe-4S ferredoxin iron-sulfur binding domain protein; SPTR: A0LP28 Formate dehydrogenase, alpha subunit; PFAM: Molybdopterin oxidoreductase; NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; 4Fe-4S bind [...]
  
 
 0.596
Your Current Organism:
Desulfarculus baarsii
NCBI taxonomy Id: 644282
Other names: D. baarsii DSM 2075, Desulfarculus baarsii 2st 14, Desulfarculus baarsii DSM 2075, Desulfarculus baarsii str. DSM 2075, Desulfarculus baarsii strain DSM 2075
Server load: low (10%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.